http://rosbnet.org/wiki/wiki/index.php?action=history&feed=atom&title=Category%3ASystems_Biology 2026-05-11T17:50:09Z Revision history for this page on the wiki MediaWiki 1.35.1 http://rosbnet.org/wiki/wiki/index.php?title=Category:Systems_Biology&diff=12&oldid=prev 2008-12-18T15:32:48Z

<p>New page: == Systems Biology == Systems Biology is an interdisciplinary field interested in the study of self-organization in biological systems. Originally beginning with a view to analyse the pro...</p> <p><b>New page</b></p><div>== Systems Biology ==<br /> <br /> Systems Biology is an interdisciplinary field interested in the study of self-organization in biological systems. Originally beginning with a view to analyse the processes that define success in the field of self-organising systems, the focus has widened; from top-down analysis, through bottom-up analysis towards a third method of middle-out understanding.<br /> <br /> Major breakthroughs of understanding have been in the field of philosophy and metaphysics and these have improved both the clarity and accuracy of predictive models.<br /> <br /> Lenny Moss (Exeter) argued for an alternative metaphysical premise; that nature explores greater levels of detachment (and complexity) and that its potential to do so can never be formally exhausted. This is the abundance-seeking phenomenon which contrasts with the environmental scarcity of [http://en.wikipedia.org/wiki/Ecological_niche Niche theory]; where a 'space of opportunity' exists in the environment and this can be explored by the biological systems within it, through their increase in detachment and complexity. <br /> &quot;Cells have to be understood via these concepts as members of populations <br /> exploring phenotype space via competitive coherence strategies (growing <br /> versus surviving, specializing versus diversifying)&quot; Vic Norris (Rouen)<br /> <br /> The growth areas of the field include the concept of: &quot;...‘understanding’ versus prediction and control, the role of hypotheses, the need for reductionism, the importance (or otherwise) of data comprehensiveness, and how interdisciplinarity could be most successfully achieved.&quot; Jane Calvert (Exeter)<br /> <br /> [http://www.genomicsnetwork.ac.uk/media/Workshop%20report.pdf Original report: Egenis, University of Exeter, November 30th – December 1st, 2006]<br /> <br /> <br /> == Sub Disciplines of Systems Biology ==<br /> <br /> [[:Category:Mathematics | Mathematics]] - For modelling the processes<br /> <br /> [[:Category:Philosophy | Philosophy]] - For explaining and predicting the models efficacy<br /> <br /> == Philosophical underpinnings of the subject ==<br /> <br /> Auffray, C., Imbeaud, S., Roux-Rouquié, M., and Hood, L. (2003). Selforganized living systems: Conjunction of a stable organization with chaotic fluctuations in biological space-time. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences,361: 1125-1139.<br /> <br /> Boogerd, F. C., Bruggeman, F. J., Richardson, R. C., Stephan, A., and Westerhoff, H. V. (2005). Emergence and its place in nature: A case study of biochemical networks. Synthese, 145: 131-64. <br /> <br /> Bruggeman, F. J., Westerhoff, H. V., and Boogerd, F. C. (2002). BioComplexity: A pluralist research strategy is necessary for a mechanistic explanation of the 'live' state. Philosophical Psychology, 15: 411- 440.<br /> <br /> Guespin, J. (1998).Réductionnisme et globalisme en biologie. [Available on request from the author.]<br /> <br /> Guespin-Michel, J., and Ripoll, C. (2000). La pluridisciplinarité dans les sciences de la vie : un nouvel obstacle pistémologique, la non linéarité. [Available on request from the author.]<br /> <br /> Norris, V., Amar, P., Bernot, G., Delaune, A., Derue, C., et al. (2004). Questions for cell cyclists. Journal of Biological Physics and Chemistry, 4: 124–130.<br /> <br /> Norris, V., Cabin, A., and Zemirline, A. (2005). Hypercomplexity. Acta Biotheoretica, 53: 313-330. Philosophical papers on emergence. <br /> <br /> Bedau, M. (1997). Weak emergence. Nous, 31: 375-399.<br /> <br /> Cunningham, C. (2000).The re-emergence of emergence. Philosophy of Science, 68: S62-S75.<br /> <br /> Klee, R. L. (1984). Micro-determinism and concepts of emergence, Philosophy of Science, 51: 44-63. 9<br /> <br /> Silberstein, M., and McGeever, J. (1999). The search for ontological emergence. The Philosophical Quarterly, 49: 182-200.<br /> <br /> <br /> == Other network Links ==<br /> <br /> [http://www.cellsignet.org.uk/ www.cellsignet.org.uk:] - a &quot;Cell Signalling Network&quot; with a balanced membership from biology and the mathematical sciences, facilitating the development of an active and cohesive cross-disciplinary community at the mathematics/systems biology interface.<br /> <br /> <br /> == Current Network System Biologists==</div>

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