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            "67": {
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                "title": "References",
                "revisions": [
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                        "*": "<center>\n<span style=\"color:#0000FF; font-size: 200%;\"><u>Please share references by adding links into this page</u></span>\n</center>\n\n\n[[Image:route.png|thumb|ACS Chem. Biol., 2008, 3 (1), pp 38\u201350|right|300px]]\n== General Principles of Synthetic Biology ==\n[http://www.nature.com/nature/journal/v438/n7067/abs/nature04335.html Reconstruction of genetic circuits]\n\n[http://www.ncbi.nlm.nih.gov/pubmed/16711359 Engineering life: building a fab for biology]\n\n[http://www.bioinfo.de/isb/2006/06/0038/ Engineering life through Synthetic Biology]\n\n[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VRV-4KPX8RY-1&_user=126524&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010360&_version=1&_urlVersion=0&_userid=126524&md5=32f32f9adee8425380015b935a6eadf8 Systems biology as a foundation for genome-scale synthetic biology]\n\n[http://www.nature.com/nature/journal/v469/n7329/full/469171a.html Synthetic biology: Division of logic labour] Cellular compartmentalization is an effective way to build gene circuits capable of complex logic operations, in which binary inputs are converted into binary outputs according to user-defined rules.\n\n== Parts Standardization/Construction ==\n[http://openwetware.org/images/9/99/Nbt1413.pdf Refinement and standardization of synthetic biological parts and devices]\n\n[http://www.jbioleng.org/content/2/1/5 Engineering BioBrick vectors from BioBrick parts]\n\n== Mathematical/Computational Methods ==\n[http://www.weizmann.ac.il/mcb/UriAlon/Papers/Shinar_Alon_Feinberg_SIAM_2009.pdf Sensitivity and robustness in chemical reaction networks]\n\n== New Designs/Design Principles ==\n[http://www.nature.com/nature/journal/v403/n6767/full/403335a0.html A synthetic oscillatory network of transcriptional regulators]\n\n[http://www.nature.com/msb/journal/v4/n1/full/msb200843.html The incoherent feed-forward loop can generate non-monotonic input functions for genes]\n\n== In-vivo/vitro Chassis ==\n[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WN5-4GS4TTH-C&_user=126524&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010360&_version=1&_urlVersion=0&_userid=126524&md5=05e4ed6bd00339746d790a93c7a96ef2 Protein synthesis by pure translation systems]\n\n[http://www.pnas.org/content/100/22/12672 Principles of cell-free genetic circuit assembly]\n\n== Applications ==\n[http://www.nature.com/msb/journal/v4/n1/full/msb200824.html A synthetic Escherichia coli predator\u2013prey ecosystem]\n\n[http://www.nature.com/nature/journal/v434/n7037/full/nature03461.html A synthetic multicellular system for programmed pattern formation]\n\n== Software Packages/Tools ==\n[http://www.mathworks.co.uk/access/helpdesk/help/toolbox/simbio/index.html?/access/helpdesk/help/toolbox/simbio/ MATLAB SimBiology]\n\n== Measurement Methods ==\n[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7CV2-4P3DWNX-S&_user=126524&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010360&_version=1&_urlVersion=0&_userid=126524&md5=179a5617e3cd099a11a4ec40f9b85780 Single-cell analysis of gene expression by fluorescence microscopy]\n\n== Ethical, Legal, and Social Issues (ELSI) ==\n\n[http://www.nature.com/nature/journal/v468/n7326/pdf/468889a.pdf Build life to understand it] Biologists and engineers should work together: synthetic biology reveals how organisms develop and function, argue Michael Elowitz and Wendell A. Lim.\n\n[http://www.synbiosafe.eu/uploads///pdf/Diffusion_of_synthetic_biology.pdf Diffusion of synthetic biology: a challenge to biosafety. Systems and Synthic Biology]\n\n[http://www.sciencemag.org/cgi/content/summary/286/5447/2087 Ethical Considerations in Synthesizing a Minimal Genome]"
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            "72": {
                "pageid": 72,
                "ns": 0,
                "title": "RoSBNet Launch Meeting",
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                        "*": "RoSBNet had its inaugural meeting on the 6 July 2009 from 3 pm onwards in the main seminar room, New Biochemistry building, Science area of the University of Oxford followed by drinks and canap\u00e9s. This was be a valuable opportunity to meet and discuss Synthetic Biology challenges and research interests with the other members of the network ahead of the main workshop scheduled for the 14 \u2013 16 September 2009. J\u00f6rg Stelling, Professor for Bioinformatics of the Swiss Federal Institute of Technology (ETH) in Z\u00fcrich giving an overview talk on Computational Engineering of Synthetic Circuits.\n\n=Programme=\n  \n3.00 - 3.30 pm: Introduction by Dr Antonis Papachristodoulou, Department of Engineering Science, University of Oxford and Prof Judith Armitage, Department of Biochemistry and Director of the Oxford Centre for Integrative Systems Biology, University of Oxford  <br>\n3.30 - 4.30 pm  Computational Engineering of Synthetic Circuits. Prof J\u00f6rg Stelling, Professor for Bioinformatics of the Swiss Federal Institute of Technology (ETH) in Z\u00fcrich. <br>\n4.30 - 5.00 pm  Discussion on Network Challenges.<br>\n5.00 - 6.00 pm  Drinks and canap\u00e9s. <br>\n\n== Abstract of main talk ==\n\n'''Computational Engineering of Synthetic Circuits'''\n\nUltimately, synthetic biology aims at establishing novel, useful biological functions by suitably combining well-characterized parts. Especially when complex circuits \u2013 in terms of the number of components and interactions involved, or with respect to the dynamic behavior \u2013 are to be designed, computational engineering methods have to be an integral part of the approach. This talk will focus on engineering concepts to achieve scalability and robustness (relative insensitivity to external or internal perturbations of the designed circuits). Both are important concerns for the field because the biology-based parts employed are not (yet) well-characterized, the circuits have to operate in a noisy (cellular) environment, and they cannot be completely isolated from, e.g., a cellular context. More specifically, major open issues exist regarding (i) principles of circuits design with standardized parts, and (ii) principles for the design of robust performance of synthetic circuits. \u2018Classical\u2019 synthetic genetic circuits as well as a tunable synthetic oscillator in mammalian cells will be discussed as prototypical examples to illustrate our current capabilities. In perspective, synthetic approaches do not only have the potential of major impacts in different application areas, but also present challenging problems for engineering design.\n\n=Registration Form=\n\nNetwork members are invited to attend this meeting. Please complete the attached Registration Form and return it by [mailto:rosbnet@eng.ox.ac.uk email] or post by Monday 15 June. Please follow this [http://www.bioch.ox.ac.uk/aspsite/index.asp?sectionid=maps link] for travel directions.\n\n[[Media:RoSBNetLaunchRegistrationForm.doc|RoSBNet Launch Registration Form in MS Word format]] \n<br>\n[[Media:RoSBNetLaunchRegistrationForm.pdf|RoSBNet Launch Registration Form in PDF format]]"
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