http://rosbnet.org/wiki/wiki/api.php?action=feedcontributions&feedformat=atom&user=AntonisRoSBNet - User contributions [en]2026-05-11T16:33:59ZUser contributionsMediaWiki 1.35.1http://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1069Welcome to RoSBNet wiki2016-12-08T23:27:59Z<p>Antonis: /* Upcoming Events */</p>
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[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
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</center><br />
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<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1068Welcome to RoSBNet wiki2015-04-06T16:26:52Z<p>Antonis: /* Upcoming Events */</p>
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<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
Italy - [http://www.taosciences.it/ssbss2015/ International Synthetic and Systems Biology Summer School]<br />
<br />
- 5 - 9 July 2015<br />
<br />
Taormina, Italy.<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1067Welcome to RoSBNet wiki2014-12-01T16:32:44Z<p>Antonis: /* Upcoming Events */</p>
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<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 24-25 February 2015.<br />
<br />
- Boston, MA, USA.<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1066Welcome to RoSBNet wiki2014-05-09T11:13:52Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
USA - [http://www.iwbdaconf.org/2014/ 6th International Workshop on Biodesign Automation]<br />
<br />
- 11-12 June 2014.<br />
<br />
- Boston, MA, USA<br />
<br />
<br />
USA - [http://www.synbioconference.org/ SEED 2014]<br />
<br />
- 14-17 July 2014.<br />
<br />
- Manhattan Beach, CA, USA.<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
Spain - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
UK - [http://sysos.eng.ox.ac.uk/control/sysos/index.php/Workshop_on_Control_Engineering_and_Synthetic_Biology Workshop on Synthetic Biology and Control]<br />
<br />
- 10-12 September 2014.<br />
<br />
- Oxford, UK. <br />
<br />
<br />
Australia - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 24-25 February 2015.<br />
<br />
- Boston, MA, USA.<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1065Welcome to RoSBNet wiki2014-04-21T14:00:04Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 3-4 June 2014.<br />
<br />
- Boston, MA, USA.<br />
<br />
<br />
USA - [http://www.synbioconference.org/ SEED 2014]<br />
<br />
- 14-17 July 2014.<br />
<br />
- Manhattan Beach, CA, USA.<br />
<br />
<br />
USA - [http://www.iwbdaconf.org/2014/ 6th International Workshop on Biodesign Automation]<br />
<br />
- 11-12 June 2014.<br />
<br />
- Boston, MA, USA<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
Spain - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
UK - [Workshop on Synthetic Biology and Control]<br />
<br />
- 10-12 September 2014.<br />
<br />
- Oxford, UK. <br />
<br />
<br />
Australia - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1064Welcome to RoSBNet wiki2014-03-08T14:22:04Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
UK - [http://synbiobeta.com/ Synbiobeta]<br />
<br />
- 3 April 2014.<br />
<br />
- London, UK.<br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 3-4 June 2014.<br />
<br />
- Boston, MA, USA.<br />
<br />
<br />
USA - [http://www.synbioconference.org/ SEED 2014]<br />
<br />
- 14-17 July 2014.<br />
<br />
- Manhattan Beach, CA, USA.<br />
<br />
<br />
USA - [http://www.iwbdaconf.org/2014/ 6th International Workshop on Biodesign Automation]<br />
<br />
- 11-12 June 2014.<br />
<br />
- Boston, MA, USA<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
Spain - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
UK - [Workshop on Synthetic Biology and Control]<br />
<br />
- 10-12 September 2014.<br />
<br />
- Oxford, UK. <br />
<br />
<br />
Australia - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1063Welcome to RoSBNet wiki2014-03-08T14:20:42Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
UK - [http://synbiobeta.com/ Synbiobeta]<br />
<br />
- 3 April 2014.<br />
<br />
- London, UK.<br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 3-4 June 2014.<br />
<br />
- Boston, MA, USA.<br />
<br />
<br />
USA - [http://www.iwbdaconf.org/2014/ 6th International Workshop on Biodesign Automation]<br />
<br />
- 11-12 June 2014.<br />
<br />
- Boston, MA, USA<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
Spain - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
UK - [Workshop on Synthetic Biology and Control]<br />
<br />
- 10-12 September 2014.<br />
<br />
- Oxford, UK. <br />
<br />
<br />
Australia - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1062Welcome to RoSBNet wiki2014-01-25T16:38:15Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
USA - [http://w-qbio.org Winter Q-bio meeting]<br />
<br />
- 17-20 February 2014.<br />
<br />
- Hawaii, USA.<br />
<br />
<br />
USA - [http://ibe.org/meetings-and-events.html Institute of Biological Engineering 2014 Annual Conference]<br />
<br />
- 6-8 March 2014.<br />
<br />
- Lexington, KY, USA.<br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 3-4 June 2014.<br />
<br />
- Boston, MA, USA.<br />
<br />
<br />
USA - [http://www.iwbdaconf.org/2014/ 6th International Workshop on Biodesign Automation]<br />
<br />
- 11-12 June 2014.<br />
<br />
- Boston, MA, USA<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
Spain - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
UK - [Workshop on Synthetic Biology and Control]<br />
<br />
- 10-12 September 2014.<br />
<br />
- Oxford, UK. <br />
<br />
<br />
Australia - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1061Welcome to RoSBNet wiki2014-01-19T18:51:04Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
USA - [http://w-qbio.org Winter Q-bio meeting]<br />
<br />
- 17-20 February 2014.<br />
<br />
- Hawaii, USA.<br />
<br />
<br />
USA - [http://ibe.org/meetings-and-events.html Institute of Biological Engineering 2014 Annual Conference]<br />
<br />
- 6-8 March 2014.<br />
<br />
- Lexington, KY, USA.<br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 3-4 June 2014.<br />
<br />
- Boston, MA, USA.<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
Spain - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
UK - [Workshop on Synthetic Biology and Control]<br />
<br />
- 10-12 September 2014.<br />
<br />
- Oxford, UK. <br />
<br />
<br />
Australia - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=MediaWiki:Sidebar&diff=1060MediaWiki:Sidebar2014-01-05T11:11:49Z<p>Antonis: </p>
<hr />
<div>* Synthetic Biology<br />
** What is Synthetic Biology? | What is Synthetic Biology?<br />
** publications | Synthetic Biology Resources<br />
** References | Some Synthetic Biology References<br />
** Other Synthetic Biology Networks | Synthetic Biology Networks<br />
<br />
* RoSBNet Network<br />
** Member List | Member List<br />
** Community_Portal | Network Resources<br />
** Third RoSBNet Workshop| Third RoSBNet Workshop<br />
** 2011 RoSBNet Meeting| January 2011 RoSBNet Meeting<br />
** Second RoSBNet Workshop| Second RoSBNet Workshop<br />
** RoSBNet Meeting| January 2010 RoSBNet Meeting<br />
** CDCPreconferenceWorkshop| CDC 2009 Preconference Workshop<br />
** First RoSBNet Workshop| First RoSBNet Workshop<br />
** RoSBNet Launch Meeting | Network Launch Meeting<br />
<br />
* External Links<br />
** Funding Bodies | Funding Bodies</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Other_Synthetic_Biology_Networks&diff=1059Other Synthetic Biology Networks2014-01-05T11:11:17Z<p>Antonis: </p>
<hr />
<div>= Networks in Synthetic Biology =<br />
RoSBNet is one of seven [http://www.bbsrc.ac.uk/funding/opportunities/2007/synthetic-biology.aspx Synthetic Biology Networks] funded by four Research Councils, the EPSRC, the BBSRC, the AHRC and the ESRC. The aim of these networks is to establish communication and networking between researchers to share ideas, and encourage creative approaches to meet future challenges. This also allows the opportunity to build international multidisciplinary partnerships to attract research funding opportunities. The seven networks are:<br />
<br />
* [http://www.rosbnet.org/ RoSBNet From Robust Synthetic Biological Parts to Whole Systems: Theoretical, Practical and Ethical Challenges]<br />
* [http://www.bris.ac.uk/scn/ Synthetic Components Network: Towards Synthetic Biology From The Bottom Up]<br />
* [http://www.sppi-net.org/index.php SPPI - Net A Network for Synthetic Plant Products for Industry]<br />
* [http://www.synbiostandards.ac.uk/index.php Standards for the Design and Engineering of modular biological devices]<br />
* [http://www.ucl.ac.uk/synbion/network Synbion: The UCL Network in Synthetic Biology] <br />
* [http://www.sheffield.ac.uk/synbio/mates MATE’s: Microbial Applications To Tissue engineering, An Exemplar Synthetic Biology]<br />
* [http://www.synbiostandards.co.uk/resources.php?type=networks SynBiont: A Synthetic Biology Network for Modelling and Programming Cell-Chell Interactions]<br />
<br />
Apart from these networks, the following activities are ongoing:<br />
<br />
* [http://www.ia-sb.eu/go/synthetic-biology International Association Synthetic Biology (IASB)] - Concerned with the scientific and economic prospects of synthetic biology, as well as with the bioethical and biosecurity questions it raises. IASB published a code of conduct in 2009. <br />
* [http://www.erasynbio.eu/project ERASynBio] - An EU FP7 ERA-NET for the development and coordination of Synthetic Biology in the European Research Area<br />
* [http://www.synbiosafe.eu/ SYNBIOSAFE Project] – An EC-FP6 project which researched the safety and ethical aspects of synthetic biology, aiming to proactively stimulate a debate on these issues. The project website has links to various publications and a list of other European synthetic biology projects.<br />
* [http://synberc.org/ Synthetic Biology Engineering Research Center (SynBERC)] - a multi-institution research effort based in the US. <br />
* [http://syntheticbiology.org/ Synthetic Biology Community] – An online group of individuals, groups and labs from various institutions. The website has links to their labs, projects, courses and online tools.<br />
* [http://www.epsrc.ac.uk/newsevents/news/2012/Pages/syntheticbiology.aspx Flowers Consortium] - A collaboration between five universities (Imperial College London, Cambridge, Edinburgh, Newcastle and King's College London) to establish a platform technology based on an information system - SynBIS - which uses a web-based environment.<br />
<br />
= The Synthetic Biology Special Interest Group =<br />
<br />
A [https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/ Synthetic Biology Special Interest Group (SynBio-SIG)] has been established as a link between the UK's research base and the relevant industrial communities. Its aim is to ensure that the UK's world-leading synthetic biology research can be translated and developed into commercial applications.</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Publications&diff=1058Publications2014-01-05T11:11:05Z<p>Antonis: </p>
<hr />
<div>== Publications/Reports related to Synthetic Biology ==<br />
<br />
There have been several reports over the years on Synthetic Biology. Here are a few - more details below:<br />
<br />
* [http://www.rcuk.ac.uk/documents/publications/SyntheticBiologyRoadmap.pdf UK roadmap for Synthetic Biology]<br />
<br />
* [http://www.bioethics.gov/documents/synthetic-biology/PCSBI-Synthetic-Biology-Report-12.16.10.pdf Presidential Commission for the Study of Bioethical Issues]: New Directions: The Ethics of Synthetic Biology and Emerging Technologies. <br />
<br />
* [[Media:Synthetic biology workshop report.pdf|BBSRC Synthetic Biology Workshop report 8-9th February 2007]]<br />
<br />
* [http://www.parliament.uk/documents/post/postpn298.pdf Parliamentary Office of Science and Technology]: Analysis of public policy issues related to synthetic biology.<br />
<br />
* [[Media:SBdialogue.pdf | BBSRC/EPSRC Synthetic Biology Dialogue]]:<br />
This report presents the findings of a series of public workshops and stakeholder interviews on the science and issues surrounding synthetic biology.<br />
<br />
* [http://kn.theiet.org/magazine/issues/0905/index.cfm Institution of Engineering and Technology: E&T Magazine]: Special issue focussing on synthetic biology.<br />
<br />
* [http://www.raeng.org.uk/news/publications/list/reports/Synthetic_biology.pdf Royal Academy of Enginnering]: Synthetic Biology: Scope, applications and implications.<br />
<br />
* [http://www.raeng.org.uk/news/publications/list/reports/Syn_bio_dialogue_report.pdf Royal Academy of Enginnering]: Synthetic Biology: Public dialogue on synthetic biology.<br />
<br />
* [http://royalsociety.org/Synthetic-biology/project/ Royal Society]: Synthetic Biology: Scientific discussion meeting summary.<br />
<br />
* [http://www.bbsrc.ac.uk/web/FILES/Reviews/0806_synthetic_biology.pdf BBSRC]: "Synthetic Biology Social and Ethical Challenges", A. Balmer and P. Martin.<br />
<br />
= A Strategic Roadmap for Synthetic Biology in the UK =<br />
<br />
A [http://www.rcuk.ac.uk/documents/publications/SyntheticBiologyRoadmap.pdf UK roadmap for Synthetic Biology], produced by an independent panel of experts for the government's Department for Business Innovation and Skills, was published in July 2012 in order to develop 'a roadmap that defines the likely timeframe and actions required to establish a world leading Synthetic Biology industry within the UK.' <br />
<br />
== Core themes ==<br />
<br />
Five core themes emerged from this work. They were:<br />
* Foundational science and engineering: the need for sufficient capabilities for the UK to maintain a leading edge<br />
* Continuing responsible research and innovation: including the need for awareness, training and adherence to regulatory frameworks<br />
* Developing technology for commercial use<br />
* Applications and markets: identifying growth markets and developing applications<br />
* International cooperation<br />
<br />
== Key recommendations == <br />
<br />
To achieve these themes, five key recommendations were outlined:<br />
* Invest in a network of multidisciplinary centres to establish an outstanding UK synthetic biology resource.<br />
* Build a skilled, energised and well-funded UK-wide synthetic biology community [for example, via the Synthetic Biology Special Interest Group].<br />
* Invest to accelerate technology responsibly to market.<br />
* Assume a leading international role.<br />
* Establish a leadership council<br />
<br />
= Synthetic Biology Leadership Council =<br />
<br />
As part of the recommendations of the Synthetic Biology roadmap for the UK, the UK Government established a Synthetic Biology Leadership Council (SBLC) as a steering structure governance body that can assess progress, update recommendations and shape priorities for future implementation of the synthetic biology roadmap for the UK.<br />
<br />
The SBLC will provide a visible point for strategic coordination between the funding agencies, the research community, industry, government sponsors and other stakeholders, including societal and ethical representatives. <br />
<br />
[https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/synbio-leadership-council Click here for more details.]<br />
<br />
= The Parliamentary Office on Science and Technology - Postnote on Synthetic Biology =<br />
<br />
The Parliamentary Office of Science and Technology produced a [http://www.parliament.uk/documents/post/postpn298.pdf Postnote] on Synthetic Biology. This helps put into context recent developments, the benefits and possible risks associated with synthetic biology together with the policy options for the development and governance of the research.<br />
<br />
Synthetic Biology could raise some concerns regarding ethics, bio security, bio safety, ownership of intellectual property and question the motivation of stakeholders. Concern is also been raised regarding the lack of proper regulation both within the Scientific Community and by governments Worldwide. <br />
<br />
= Synthetic Biology Dialogue Report =<br />
<br />
To address public opinion the Biotechnology and Biological Sciences Research Council (BBSRC) and the Engineering and Physical Sciences Research Council (EPSRC) initiated a project to develop a dialogue with the public regarding their concerns and aspirations for this emerging field. (These institutions invest over a billion pounds of public money annually in the engineering, physical and biosciences with a clear strategic focus on improving the quality of life in the UK)<br />
<br />
The findings of the [http://www.bbsrc.ac.uk/web/FILES/Reviews/1006-synthetic-biology-dialogue.pdf Synthetic Biology Dialogue Report] were published at a launch event in London on 14 June 2010.<br />
<br />
The report presents the findings of a series of public workshops and stakeholder interviews on the science and issues surrounding synthetic biology. The Project took place during 2009-2010 and was carried out by the TNS-BMRB, BBSRC, EPSRC with the support of the Department for Business, Innovation and Skills Sciencewise programme.<br />
<br />
The public can see the enormous potential of science but are concerned about the speed of progress, regulation and the risks of synthetic biology to health and the environment. <br />
In the future Research Councils will have to consider the technical and ethical issues connected to research and reflect on the motivation and leadership within the scientific community. Although International co-ordination of regulation was raised, in the context of technical advances in a global economy the challenges faced will make this difficult to implement. More information is available [http://www.epsrc.ac.uk/newsevents/news/2010/Pages/syntheticbiology.aspx here].<br />
<br />
A [http://www.bbsrc.ac.uk/web/FILES/Reviews/synbio_summary-report.pdf Synthetic Biology Overview Report]was published in February 2011 which gives a summary of the key findings.</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1057Welcome to RoSBNet wiki2014-01-05T11:08:40Z<p>Antonis: /* Introduction to RoSBNet */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
UK - [http://www.sebiology.org/meetings/synthetic_biology/overview.html Synthetic Biology 2014]<br />
<br />
- 8-10 January 2014.<br />
<br />
- Society of Experimental Biology, Charles Darwin House, London.<br />
<br />
<br />
USA - [http://w-qbio.org Winter Q-bio meeting]<br />
<br />
- 17-20 February 2014.<br />
<br />
- Hawaii, USA.<br />
<br />
<br />
USA - [http://ibe.org/meetings-and-events.html Institute of Biological Engineering 2014 Annual Conference]<br />
<br />
- 6-8 March 2014.<br />
<br />
- Lexington, KY, USA.<br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 3-4 June 2014.<br />
<br />
- Boston, MA, USA.<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
Spain - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
Australia - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> '''While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community.''' </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1056Welcome to RoSBNet wiki2014-01-05T11:08:23Z<p>Antonis: /* Introduction to RoSBNet */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
UK - [http://www.sebiology.org/meetings/synthetic_biology/overview.html Synthetic Biology 2014]<br />
<br />
- 8-10 January 2014.<br />
<br />
- Society of Experimental Biology, Charles Darwin House, London.<br />
<br />
<br />
USA - [http://w-qbio.org Winter Q-bio meeting]<br />
<br />
- 17-20 February 2014.<br />
<br />
- Hawaii, USA.<br />
<br />
<br />
USA - [http://ibe.org/meetings-and-events.html Institute of Biological Engineering 2014 Annual Conference]<br />
<br />
- 6-8 March 2014.<br />
<br />
- Lexington, KY, USA.<br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 3-4 June 2014.<br />
<br />
- Boston, MA, USA.<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
Spain - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
Australia - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
<center> While the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. </center><br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=MediaWiki:Sidebar&diff=1055MediaWiki:Sidebar2014-01-04T16:53:15Z<p>Antonis: </p>
<hr />
<div>* Synthetic Biology<br />
** What is Synthetic Biology? | What is Synthetic Biology?<br />
** publications | Synthetic Biology Resources<br />
** References | Some Synthetic Biology References<br />
<br />
* RoSBNet Network<br />
** Member List | Member List<br />
** Community_Portal | Network Resources<br />
** Third RoSBNet Workshop| Third RoSBNet Workshop<br />
** 2011 RoSBNet Meeting| January 2011 RoSBNet Meeting<br />
** Second RoSBNet Workshop| Second RoSBNet Workshop<br />
** RoSBNet Meeting| January 2010 RoSBNet Meeting<br />
** CDCPreconferenceWorkshop| CDC 2009 Preconference Workshop<br />
** First RoSBNet Workshop| First RoSBNet Workshop<br />
** RoSBNet Launch Meeting | Network Launch Meeting<br />
<br />
* External Links<br />
** Other Synthetic Biology Networks | Other Networks<br />
** Funding Bodies | Funding Bodies</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Publications&diff=1054Publications2014-01-04T16:49:02Z<p>Antonis: /* Publications/Reports related to Synthetic Biology */</p>
<hr />
<div>== Publications/Reports related to Synthetic Biology ==<br />
<br />
[http://www.bioethics.gov/documents/synthetic-biology/PCSBI-Synthetic-Biology-Report-12.16.10.pdf Presidential Commission for the Study of Bioethical Issues]: New Directions: The Ethics of Synthetic Biology and Emerging Technologies. <br />
<br />
[[Media:Synthetic biology workshop report.pdf|BBSRC Synthetic Biology Workshop report 8-9th February 2007]]<br />
<br />
[http://www.parliament.uk/documents/post/postpn298.pdf Parliamentary Office of Science and Technology]: Analysis of public policy issues related to synthetic biology.<br />
<br />
[[Media:SBdialogue.pdf | BBSRC/EPSRC Synthetic Biology Dialogue]]:<br />
This report presents the findings of a series of public workshops and stakeholder interviews on the science and issues surrounding synthetic biology.<br />
<br />
[http://kn.theiet.org/magazine/issues/0905/index.cfm Institution of Engineering and Technology: E&T Magazine]: Special issue focussing on synthetic biology.<br />
<br />
[http://www.raeng.org.uk/news/publications/list/reports/Synthetic_biology.pdf Royal Academy of Enginnering]: Synthetic Biology: Scope, applications and implications.<br />
<br />
[http://www.raeng.org.uk/news/publications/list/reports/Syn_bio_dialogue_report.pdf Royal Academy of Enginnering]: Synthetic Biology: Public dialogue on synthetic biology.<br />
<br />
[http://royalsociety.org/Synthetic-biology/project/ Royal Society]: Synthetic Biology: Scientific discussion meeting summary.<br />
<br />
[http://www.bbsrc.ac.uk/web/FILES/Reviews/0806_synthetic_biology.pdf BBSRC]: "Synthetic Biology Social and Ethical Challenges", A. Balmer and P. Martin.<br />
<br />
= The Parliamentary Office on Science and Technology - Postnote on Synthetic Biology =<br />
<br />
The Parliamentary Office of Science and Technology produced a [http://www.parliament.uk/documents/post/postpn298.pdf Postnote] on Synthetic Biology. This helps put into context recent developments, the benefits and possible risks associated with synthetic biology together with the policy options for the development and governance of the research.<br />
<br />
Synthetic Biology could raise some concerns regarding ethics, bio security, bio safety, ownership of intellectual property and question the motivation of stakeholders. Concern is also been raised regarding the lack of proper regulation both within the Scientific Community and by governments Worldwide. <br />
<br />
= Synthetic Biology Dialogue Report =<br />
<br />
To address public opinion the Biotechnology and Biological Sciences Research Council (BBSRC) and the Engineering and Physical Sciences Research Council (EPSRC) initiated a project to develop a dialogue with the public regarding their concerns and aspirations for this emerging field. (These institutions invest over a billion pounds of public money annually in the engineering, physical and biosciences with a clear strategic focus on improving the quality of life in the UK)<br />
<br />
The findings of the [http://www.bbsrc.ac.uk/web/FILES/Reviews/1006-synthetic-biology-dialogue.pdf Synthetic Biology Dialogue Report] were published at a launch event in London on 14 June 2010.<br />
<br />
The report presents the findings of a series of public workshops and stakeholder interviews on the science and issues surrounding synthetic biology. The Project took place during 2009-2010 and was carried out by the TNS-BMRB, BBSRC, EPSRC with the support of the Department for Business, Innovation and Skills Sciencewise programme.<br />
<br />
The public can see the enormous potential of science but are concerned about the speed of progress, regulation and the risks of synthetic biology to health and the environment. <br />
In the future Research Councils will have to consider the technical and ethical issues connected to research and reflect on the motivation and leadership within the scientific community. Although International co-ordination of regulation was raised, in the context of technical advances in a global economy the challenges faced will make this difficult to implement. More information is available [http://www.epsrc.ac.uk/newsevents/news/2010/Pages/syntheticbiology.aspx here].<br />
<br />
A [http://www.bbsrc.ac.uk/web/FILES/Reviews/synbio_summary-report.pdf Synthetic Biology Overview Report]was published in February 2011 which gives a summary of the key findings.<br />
<br />
= Networks in Synthetic Biology =<br />
RoSBNet is one of seven [http://www.bbsrc.ac.uk/funding/opportunities/2007/synthetic-biology.aspx Synthetic Biology Networks] funded by four Research Councils, the EPSRC, the BBSRC, the AHRC and the ESRC. The aim of these networks is to establish communication and networking between researchers to share ideas, and encourage creative approaches to meet future challenges. This also allows the opportunity to build international multidisciplinary partnerships to attract research funding opportunities. The seven networks are:<br />
<br />
* [http://www.rosbnet.org/ RoSBNet From Robust Synthetic Biological Parts to Whole Systems: Theoretical, Practical and Ethical Challenges]<br />
* [http://www.bris.ac.uk/scn/ Synthetic Components Network: Towards Synthetic Biology From The Bottom Up]<br />
* [http://www.sppi-net.org/index.php SPPI - Net A Network for Synthetic Plant Products for Industry]<br />
* [http://www.synbiostandards.ac.uk/index.php Standards for the Design and Engineering of modular biological devices]<br />
* [http://www.ucl.ac.uk/synbion/network Synbion: The UCL Network in Synthetic Biology] <br />
* [http://www.sheffield.ac.uk/synbio/mates MATE’s: Microbial Applications To Tissue engineering, An Exemplar Synthetic Biology]<br />
* [http://www.synbiostandards.co.uk/resources.php?type=networks SynBiont: A Synthetic Biology Network for Modelling and Programming Cell-Chell Interactions]<br />
<br />
Apart from these networks, the following activities are ongoing:<br />
<br />
* [http://www.ia-sb.eu/go/synthetic-biology International Association Synthetic Biology (IASB)] - Concerned with the scientific and economic prospects of synthetic biology, as well as with the bioethical and biosecurity questions it raises. IASB published a code of conduct in 2009. <br />
* [http://www.erasynbio.eu/project ERASynBio] - An EU FP7 ERA-NET for the development and coordination of Synthetic Biology in the European Research Area<br />
* [http://www.synbiosafe.eu/ SYNBIOSAFE Project] – An EC-FP6 project which researched the safety and ethical aspects of synthetic biology, aiming to proactively stimulate a debate on these issues. The project website has links to various publications and a list of other European synthetic biology projects.<br />
* [http://synberc.org/ Synthetic Biology Engineering Research Center (SynBERC)] - a multi-institution research effort based in the US. <br />
* [http://syntheticbiology.org/ Synthetic Biology Community] – An online group of individuals, groups and labs from various institutions. The website has links to their labs, projects, courses and online tools.<br />
* [http://www.epsrc.ac.uk/newsevents/news/2012/Pages/syntheticbiology.aspx Flowers Consortium] - A collaboration between five universities (Imperial College London, Cambridge, Edinburgh, Newcastle and King's College London) to establish a platform technology based on an information system - SynBIS - which uses a web-based environment.<br />
<br />
= The Synthetic Biology Special Interest Group =<br />
<br />
A [https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/ Synthetic Biology Special Interest Group (SynBio-SIG)] has been established as a link between the UK's research base and the relevant industrial communities. Its aim is to ensure that the UK's world-leading synthetic biology research can be translated and developed into commercial applications. <br />
<br />
= A Strategic Roadmap for Synthetic Biology in the UK =<br />
<br />
A [http://www.rcuk.ac.uk/documents/publications/SyntheticBiologyRoadmap.pdf UK roadmap for Synthetic Biology], produced by an independent panel of experts for the government's Department for Business Innovation and Skills, was published in July 2012 in order to develop 'a roadmap that defines the likely timeframe and actions required to establish a world leading Synthetic Biology industry within the UK.' <br />
<br />
== Core themes ==<br />
<br />
Five core themes emerged from this work. They were:<br />
* Foundational science and engineering: the need for sufficient capabilities for the UK to maintain a leading edge<br />
* Continuing responsible research and innovation: including the need for awareness, training and adherence to regulatory frameworks<br />
* Developing technology for commercial use<br />
* Applications and markets: identifying growth markets and developing applications<br />
* International cooperation<br />
<br />
== Key recommendations == <br />
<br />
To achieve these themes, five key recommendations were outlined:<br />
* Invest in a network of multidisciplinary centres to establish an outstanding UK synthetic biology resource.<br />
* Build a skilled, energised and well-funded UK-wide synthetic biology community [for example, via the Synthetic Biology Special Interest Group].<br />
* Invest to accelerate technology responsibly to market.<br />
* Assume a leading international role.<br />
* Establish a leadership council<br />
<br />
= Synthetic Biology Leadership Council =<br />
<br />
As part of the recommendations of the Synthetic Biology roadmap for the UK, the UK Government established a Synthetic Biology Leadership Council (SBLC) as a steering structure governance body that can assess progress, update recommendations and shape priorities for future implementation of the synthetic biology roadmap for the UK.<br />
<br />
The SBLC will provide a visible point for strategic coordination between the funding agencies, the research community, industry, government sponsors and other stakeholders, including societal and ethical representatives. <br />
<br />
[https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/synbio-leadership-council Click here for more details.]</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=What_is_Synthetic_Biology%3F&diff=1053What is Synthetic Biology?2014-01-04T16:48:31Z<p>Antonis: </p>
<hr />
<div>=Synthetic Biology – What’s it all about?= <br />
<br />
Synthetic Biology is a new research area which brings together Scientists and Engineers from a wide variety of backgrounds. Its aim is to develop new technologies that have the potential to contribute to resolving the many challenges facing the 21st Century society. <br />
<br />
The many possible applications cover several areas, and are perhaps best known for advances already made in the medical field by producing at low cost a precursor to the chemical compound artemisinin which is used in anti-malarian drugs. The benefits are far reaching and will eventually include energy and the environment: for example, in the future this could include making devices to produce fuel from waste; soaking up carbon from the atmosphere and locking it away to help towards reducing global warming; the synthesis of plastics not using oil as world reserves dwindle; developing devises to sense pollutants and aid dispersal to prevent environmental disasters, etc.<br />
<br />
The driving force is to improve and enhance the quality of daily life for millions in a positive way, but through a planned and responsible approach.<br />
<br />
= How does Synthetic Biology work? =<br />
<br />
Essentially Synthetic Biology involves the design and construction of new biological functions and systems not found in nature. It first began with the study of natural chemicals and the design of new chemical compounds in the field of synthetic chemistry which has been with us for the past 100 years. <br />
<br />
This was revolutionised in the 1970’s with the breakthrough research carried out by scientists on the sequencing of DNA which lead to a greater understanding of naturally occurring organisms and the construction of parts now commonly referred to as “gene synthesis”.<br />
<br />
This led to Werner, Arber, Nathans, Hamilton and Smith receiving the Nobel Prize in 1978 for their work on “restrictive enzymes” which led to a toolkit where it was possible to create specific genetic modification in organisms which we know today as “Genetic Engineering” where segments of DNA could be taken from one organism and put into another. This resulted in the development of the Biotech Industry. <br />
<br />
The core notion is to produce “BioBricks” or Standard biological parts so that organisms can be easily reproduced and manipulated to perform special functions more efficiently or perhaps manipulated to fulfil entirely new functions. <br />
<br />
At this stage modelling allows synthetic biologists to better predict system behaviour, this is essential because precise and quantitative measurements of biological systems are important for improving the development and understanding of biology.</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=What_is_Synthetic_Biology%3F&diff=1052What is Synthetic Biology?2014-01-04T16:47:45Z<p>Antonis: /* Networks in Synthetic Biology */</p>
<hr />
<div>=Synthetic Biology – What’s it all about?= <br />
<br />
Synthetic Biology is a new research area which brings together Scientists and Engineers from a wide variety of backgrounds. Its aim is to develop new technologies that have the potential to contribute to resolving the many challenges facing the 21st Century society. <br />
<br />
The many possible applications cover several areas, and are perhaps best known for advances already made in the medical field by producing at low cost a precursor to the chemical compound artemisinin which is used in anti-malarian drugs. The benefits are far reaching and will eventually include energy and the environment: for example, in the future this could include making devices to produce fuel from waste; soaking up carbon from the atmosphere and locking it away to help towards reducing global warming; the synthesis of plastics not using oil as world reserves dwindle; developing devises to sense pollutants and aid dispersal to prevent environmental disasters, etc.<br />
<br />
The driving force is to improve and enhance the quality of daily life for millions in a positive way, but through a planned and responsible approach.<br />
<br />
= How does Synthetic Biology work? =<br />
<br />
Essentially Synthetic Biology involves the design and construction of new biological functions and systems not found in nature. It first began with the study of natural chemicals and the design of new chemical compounds in the field of synthetic chemistry which has been with us for the past 100 years. <br />
<br />
This was revolutionised in the 1970’s with the breakthrough research carried out by scientists on the sequencing of DNA which lead to a greater understanding of naturally occurring organisms and the construction of parts now commonly referred to as “gene synthesis”.<br />
<br />
This led to Werner, Arber, Nathans, Hamilton and Smith receiving the Nobel Prize in 1978 for their work on “restrictive enzymes” which led to a toolkit where it was possible to create specific genetic modification in organisms which we know today as “Genetic Engineering” where segments of DNA could be taken from one organism and put into another. This resulted in the development of the Biotech Industry. <br />
<br />
The core notion is to produce “BioBricks” or Standard biological parts so that organisms can be easily reproduced and manipulated to perform special functions more efficiently or perhaps manipulated to fulfil entirely new functions. <br />
<br />
At this stage modelling allows synthetic biologists to better predict system behaviour, this is essential because precise and quantitative measurements of biological systems are important for improving the development and understanding of biology.<br />
<br />
= The Parliamentary Office on Science and Technology - Postnote on Synthetic Biology =<br />
<br />
The Parliamentary Office of Science and Technology produced a [http://www.parliament.uk/documents/post/postpn298.pdf Postnote] on Synthetic Biology. This helps put into context recent developments, the benefits and possible risks associated with synthetic biology together with the policy options for the development and governance of the research.<br />
<br />
Synthetic Biology could raise some concerns regarding ethics, bio security, bio safety, ownership of intellectual property and question the motivation of stakeholders. Concern is also been raised regarding the lack of proper regulation both within the Scientific Community and by governments Worldwide. <br />
<br />
= Synthetic Biology Dialogue Report =<br />
<br />
To address public opinion the Biotechnology and Biological Sciences Research Council (BBSRC) and the Engineering and Physical Sciences Research Council (EPSRC) initiated a project to develop a dialogue with the public regarding their concerns and aspirations for this emerging field. (These institutions invest over a billion pounds of public money annually in the engineering, physical and biosciences with a clear strategic focus on improving the quality of life in the UK)<br />
<br />
The findings of the [http://www.bbsrc.ac.uk/web/FILES/Reviews/1006-synthetic-biology-dialogue.pdf Synthetic Biology Dialogue Report] were published at a launch event in London on 14 June 2010.<br />
<br />
The report presents the findings of a series of public workshops and stakeholder interviews on the science and issues surrounding synthetic biology. The Project took place during 2009-2010 and was carried out by the TNS-BMRB, BBSRC, EPSRC with the support of the Department for Business, Innovation and Skills Sciencewise programme.<br />
<br />
The public can see the enormous potential of science but are concerned about the speed of progress, regulation and the risks of synthetic biology to health and the environment. <br />
In the future Research Councils will have to consider the technical and ethical issues connected to research and reflect on the motivation and leadership within the scientific community. Although International co-ordination of regulation was raised, in the context of technical advances in a global economy the challenges faced will make this difficult to implement. More information is available [http://www.epsrc.ac.uk/newsevents/news/2010/Pages/syntheticbiology.aspx here].<br />
<br />
A [http://www.bbsrc.ac.uk/web/FILES/Reviews/synbio_summary-report.pdf Synthetic Biology Overview Report]was published in February 2011 which gives a summary of the key findings.<br />
<br />
= Networks in Synthetic Biology =<br />
RoSBNet is one of seven [http://www.bbsrc.ac.uk/funding/opportunities/2007/synthetic-biology.aspx Synthetic Biology Networks] funded by four Research Councils, the EPSRC, the BBSRC, the AHRC and the ESRC. The aim of these networks is to establish communication and networking between researchers to share ideas, and encourage creative approaches to meet future challenges. This also allows the opportunity to build international multidisciplinary partnerships to attract research funding opportunities. The seven networks are:<br />
<br />
* [http://www.rosbnet.org/ RoSBNet From Robust Synthetic Biological Parts to Whole Systems: Theoretical, Practical and Ethical Challenges]<br />
* [http://www.bris.ac.uk/scn/ Synthetic Components Network: Towards Synthetic Biology From The Bottom Up]<br />
* [http://www.sppi-net.org/index.php SPPI - Net A Network for Synthetic Plant Products for Industry]<br />
* [http://www.synbiostandards.ac.uk/index.php Standards for the Design and Engineering of modular biological devices]<br />
* [http://www.ucl.ac.uk/synbion/network Synbion: The UCL Network in Synthetic Biology] <br />
* [http://www.sheffield.ac.uk/synbio/mates MATE’s: Microbial Applications To Tissue engineering, An Exemplar Synthetic Biology]<br />
* [http://www.synbiostandards.co.uk/resources.php?type=networks SynBiont: A Synthetic Biology Network for Modelling and Programming Cell-Chell Interactions]<br />
<br />
Apart from these networks, the following activities are ongoing:<br />
<br />
* [http://www.ia-sb.eu/go/synthetic-biology International Association Synthetic Biology (IASB)] - Concerned with the scientific and economic prospects of synthetic biology, as well as with the bioethical and biosecurity questions it raises. IASB published a code of conduct in 2009. <br />
* [http://www.erasynbio.eu/project ERASynBio] - An EU FP7 ERA-NET for the development and coordination of Synthetic Biology in the European Research Area<br />
* [http://www.synbiosafe.eu/ SYNBIOSAFE Project] – An EC-FP6 project which researched the safety and ethical aspects of synthetic biology, aiming to proactively stimulate a debate on these issues. The project website has links to various publications and a list of other European synthetic biology projects.<br />
* [http://synberc.org/ Synthetic Biology Engineering Research Center (SynBERC)] - a multi-institution research effort based in the US. <br />
* [http://syntheticbiology.org/ Synthetic Biology Community] – An online group of individuals, groups and labs from various institutions. The website has links to their labs, projects, courses and online tools.<br />
* [http://www.epsrc.ac.uk/newsevents/news/2012/Pages/syntheticbiology.aspx Flowers Consortium] - A collaboration between five universities (Imperial College London, Cambridge, Edinburgh, Newcastle and King's College London) to establish a platform technology based on an information system - SynBIS - which uses a web-based environment.<br />
<br />
= The Synthetic Biology Special Interest Group =<br />
<br />
A [https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/ Synthetic Biology Special Interest Group (SynBio-SIG)] has been established as a link between the UK's research base and the relevant industrial communities. Its aim is to ensure that the UK's world-leading synthetic biology research can be translated and developed into commercial applications. <br />
<br />
= A Strategic Roadmap for Synthetic Biology in the UK =<br />
<br />
A [http://www.rcuk.ac.uk/documents/publications/SyntheticBiologyRoadmap.pdf UK roadmap for Synthetic Biology], produced by an independent panel of experts for the government's Department for Business Innovation and Skills, was published in July 2012 in order to develop 'a roadmap that defines the likely timeframe and actions required to establish a world leading Synthetic Biology industry within the UK.' <br />
<br />
== Core themes ==<br />
<br />
Five core themes emerged from this work. They were:<br />
* Foundational science and engineering: the need for sufficient capabilities for the UK to maintain a leading edge<br />
* Continuing responsible research and innovation: including the need for awareness, training and adherence to regulatory frameworks<br />
* Developing technology for commercial use<br />
* Applications and markets: identifying growth markets and developing applications<br />
* International cooperation<br />
<br />
== Key recommendations == <br />
<br />
To achieve these themes, five key recommendations were outlined:<br />
* Invest in a network of multidisciplinary centres to establish an outstanding UK synthetic biology resource.<br />
* Build a skilled, energised and well-funded UK-wide synthetic biology community [for example, via the Synthetic Biology Special Interest Group].<br />
* Invest to accelerate technology responsibly to market.<br />
* Assume a leading international role.<br />
* Establish a leadership council<br />
<br />
= Synthetic Biology Leadership Council =<br />
<br />
As part of the recommendations of the Synthetic Biology roadmap for the UK, the UK Government established a Synthetic Biology Leadership Council (SBLC) as a steering structure governance body that can assess progress, update recommendations and shape priorities for future implementation of the synthetic biology roadmap for the UK.<br />
<br />
The SBLC will provide a visible point for strategic coordination between the funding agencies, the research community, industry, government sponsors and other stakeholders, including societal and ethical representatives. <br />
<br />
[https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/synbio-leadership-council Click here for more details.]</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=What_is_Synthetic_Biology%3F&diff=1051What is Synthetic Biology?2014-01-04T16:25:51Z<p>Antonis: /* Networks in Synthetic Biology */</p>
<hr />
<div>=Synthetic Biology – What’s it all about?= <br />
<br />
Synthetic Biology is a new research area which brings together Scientists and Engineers from a wide variety of backgrounds. Its aim is to develop new technologies that have the potential to contribute to resolving the many challenges facing the 21st Century society. <br />
<br />
The many possible applications cover several areas, and are perhaps best known for advances already made in the medical field by producing at low cost a precursor to the chemical compound artemisinin which is used in anti-malarian drugs. The benefits are far reaching and will eventually include energy and the environment: for example, in the future this could include making devices to produce fuel from waste; soaking up carbon from the atmosphere and locking it away to help towards reducing global warming; the synthesis of plastics not using oil as world reserves dwindle; developing devises to sense pollutants and aid dispersal to prevent environmental disasters, etc.<br />
<br />
The driving force is to improve and enhance the quality of daily life for millions in a positive way, but through a planned and responsible approach.<br />
<br />
= How does Synthetic Biology work? =<br />
<br />
Essentially Synthetic Biology involves the design and construction of new biological functions and systems not found in nature. It first began with the study of natural chemicals and the design of new chemical compounds in the field of synthetic chemistry which has been with us for the past 100 years. <br />
<br />
This was revolutionised in the 1970’s with the breakthrough research carried out by scientists on the sequencing of DNA which lead to a greater understanding of naturally occurring organisms and the construction of parts now commonly referred to as “gene synthesis”.<br />
<br />
This led to Werner, Arber, Nathans, Hamilton and Smith receiving the Nobel Prize in 1978 for their work on “restrictive enzymes” which led to a toolkit where it was possible to create specific genetic modification in organisms which we know today as “Genetic Engineering” where segments of DNA could be taken from one organism and put into another. This resulted in the development of the Biotech Industry. <br />
<br />
The core notion is to produce “BioBricks” or Standard biological parts so that organisms can be easily reproduced and manipulated to perform special functions more efficiently or perhaps manipulated to fulfil entirely new functions. <br />
<br />
At this stage modelling allows synthetic biologists to better predict system behaviour, this is essential because precise and quantitative measurements of biological systems are important for improving the development and understanding of biology.<br />
<br />
= The Parliamentary Office on Science and Technology - Postnote on Synthetic Biology =<br />
<br />
The Parliamentary Office of Science and Technology produced a [http://www.parliament.uk/documents/post/postpn298.pdf Postnote] on Synthetic Biology. This helps put into context recent developments, the benefits and possible risks associated with synthetic biology together with the policy options for the development and governance of the research.<br />
<br />
Synthetic Biology could raise some concerns regarding ethics, bio security, bio safety, ownership of intellectual property and question the motivation of stakeholders. Concern is also been raised regarding the lack of proper regulation both within the Scientific Community and by governments Worldwide. <br />
<br />
= Synthetic Biology Dialogue Report =<br />
<br />
To address public opinion the Biotechnology and Biological Sciences Research Council (BBSRC) and the Engineering and Physical Sciences Research Council (EPSRC) initiated a project to develop a dialogue with the public regarding their concerns and aspirations for this emerging field. (These institutions invest over a billion pounds of public money annually in the engineering, physical and biosciences with a clear strategic focus on improving the quality of life in the UK)<br />
<br />
The findings of the [http://www.bbsrc.ac.uk/web/FILES/Reviews/1006-synthetic-biology-dialogue.pdf Synthetic Biology Dialogue Report] were published at a launch event in London on 14 June 2010.<br />
<br />
The report presents the findings of a series of public workshops and stakeholder interviews on the science and issues surrounding synthetic biology. The Project took place during 2009-2010 and was carried out by the TNS-BMRB, BBSRC, EPSRC with the support of the Department for Business, Innovation and Skills Sciencewise programme.<br />
<br />
The public can see the enormous potential of science but are concerned about the speed of progress, regulation and the risks of synthetic biology to health and the environment. <br />
In the future Research Councils will have to consider the technical and ethical issues connected to research and reflect on the motivation and leadership within the scientific community. Although International co-ordination of regulation was raised, in the context of technical advances in a global economy the challenges faced will make this difficult to implement. More information is available [http://www.epsrc.ac.uk/newsevents/news/2010/Pages/syntheticbiology.aspx here].<br />
<br />
A [http://www.bbsrc.ac.uk/web/FILES/Reviews/synbio_summary-report.pdf Synthetic Biology Overview Report]was published in February 2011 which gives a summary of the key findings.<br />
<br />
= Networks in Synthetic Biology =<br />
RoSBNet is one of seven [http://www.bbsrc.ac.uk/funding/opportunities/2007/synthetic-biology.aspx Synthetic Biology Networks] funded by four Research Councils, the EPSRC, the BBSRC, the AHRC and the ESRC. The aim of these networks is to establish communication and networking between researchers to share ideas, and encourage creative approaches to meet future challenges. This also allows the opportunity to build international multidisciplinary partnerships to attract research funding opportunities. The seven networks are:<br />
<br />
* [http://www.rosbnet.org/ RoSBNet From Robust Synthetic Biological Parts to Whole Systems: Theoretical, Practical and Ethical Challenges]<br />
* [http://www.bris.ac.uk/scn/ Synthetic Components Network: Towards Synthetic Biology From The Bottom Up]<br />
* [http://www.sppi-net.org/index.php SPPI - Net A Network for Synthetic Plant Products for Industry]<br />
* [http://www.synbiostandards.ac.uk/index.php Standards for the Design and Engineering of modular biological devices]<br />
* [http://www.ucl.ac.uk/synbion/network Synbion: The UCL Network in Synthetic Biology] <br />
* [http://www.sheffield.ac.uk/synbio/mates MATE’s: Microbial Applications To Tissue engineering, An Exemplar Synthetic Biology]<br />
* [http://www.synbiostandards.co.uk/resources.php?type=networks SynBiont: A Synthetic Biology Network for Modelling and Programming Cell-Chell Interactions]<br />
<br />
Apart from these networks, the following activities are ongoing:<br />
<br />
* [http://www.erasynbio.eu/project ERASynBio] - An EU FP7 ERA-NET for the development and coordination of Synthetic Biology in the European Research Area<br />
* [http://www.epsrc.ac.uk/newsevents/news/2012/Pages/syntheticbiology.aspx Flowers Consortium] - A collaboration between five universities (Imperial College London, Cambridge, Edinburgh, Newcastle and King's College London) to establish a platform technology based on an information system - SynBIS - which uses a web-based environment.<br />
* [http://syntheticbiology.org/ Synthetic Biology Community] – An online group of individuals, groups and labs from various institutions. The website has links to their labs, projects, courses and online tools.<br />
* [http://www.synbiosafe.eu/ SYNBIOSAFE Project] – An EC-FP6 project which researched the safety and ethical aspects of synthetic biology, aiming to proactively stimulate a debate on these issues. The project website has links to various publications and a list of other European synthetic biology projects. http://www.synbiosafe.eu<br />
* [http://synberc.org/ Synthetic Biology Engineering Research Center (SynBERC)] - a multi-institution research effort based in the US. <br />
* [http://www.ia-sb.eu/go/synthetic-biology International Association Synthetic Biology (IASB)] - Concerned with the scientific and economic prospects of synthetic biology, as well as with the bioethical and biosecurity questions it raises. IASB published a code of conduct in 2009. http://www.ia-sb.eu/go/synthetic-biology<br />
<br />
= The Synthetic Biology Special Interest Group =<br />
<br />
A [https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/ Synthetic Biology Special Interest Group (SynBio-SIG)] has been established as a link between the UK's research base and the relevant industrial communities. Its aim is to ensure that the UK's world-leading synthetic biology research can be translated and developed into commercial applications. <br />
<br />
= A Strategic Roadmap for Synthetic Biology in the UK =<br />
<br />
A [http://www.rcuk.ac.uk/documents/publications/SyntheticBiologyRoadmap.pdf UK roadmap for Synthetic Biology], produced by an independent panel of experts for the government's Department for Business Innovation and Skills, was published in July 2012 in order to develop 'a roadmap that defines the likely timeframe and actions required to establish a world leading Synthetic Biology industry within the UK.' <br />
<br />
== Core themes ==<br />
<br />
Five core themes emerged from this work. They were:<br />
* Foundational science and engineering: the need for sufficient capabilities for the UK to maintain a leading edge<br />
* Continuing responsible research and innovation: including the need for awareness, training and adherence to regulatory frameworks<br />
* Developing technology for commercial use<br />
* Applications and markets: identifying growth markets and developing applications<br />
* International cooperation<br />
<br />
== Key recommendations == <br />
<br />
To achieve these themes, five key recommendations were outlined:<br />
* Invest in a network of multidisciplinary centres to establish an outstanding UK synthetic biology resource.<br />
* Build a skilled, energised and well-funded UK-wide synthetic biology community [for example, via the Synthetic Biology Special Interest Group].<br />
* Invest to accelerate technology responsibly to market.<br />
* Assume a leading international role.<br />
* Establish a leadership council<br />
<br />
= Synthetic Biology Leadership Council =<br />
<br />
As part of the recommendations of the Synthetic Biology roadmap for the UK, the UK Government established a Synthetic Biology Leadership Council (SBLC) as a steering structure governance body that can assess progress, update recommendations and shape priorities for future implementation of the synthetic biology roadmap for the UK.<br />
<br />
The SBLC will provide a visible point for strategic coordination between the funding agencies, the research community, industry, government sponsors and other stakeholders, including societal and ethical representatives. <br />
<br />
[https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/synbio-leadership-council Click here for more details.]</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=What_is_Synthetic_Biology%3F&diff=1050What is Synthetic Biology?2014-01-04T16:17:46Z<p>Antonis: </p>
<hr />
<div>=Synthetic Biology – What’s it all about?= <br />
<br />
Synthetic Biology is a new research area which brings together Scientists and Engineers from a wide variety of backgrounds. Its aim is to develop new technologies that have the potential to contribute to resolving the many challenges facing the 21st Century society. <br />
<br />
The many possible applications cover several areas, and are perhaps best known for advances already made in the medical field by producing at low cost a precursor to the chemical compound artemisinin which is used in anti-malarian drugs. The benefits are far reaching and will eventually include energy and the environment: for example, in the future this could include making devices to produce fuel from waste; soaking up carbon from the atmosphere and locking it away to help towards reducing global warming; the synthesis of plastics not using oil as world reserves dwindle; developing devises to sense pollutants and aid dispersal to prevent environmental disasters, etc.<br />
<br />
The driving force is to improve and enhance the quality of daily life for millions in a positive way, but through a planned and responsible approach.<br />
<br />
= How does Synthetic Biology work? =<br />
<br />
Essentially Synthetic Biology involves the design and construction of new biological functions and systems not found in nature. It first began with the study of natural chemicals and the design of new chemical compounds in the field of synthetic chemistry which has been with us for the past 100 years. <br />
<br />
This was revolutionised in the 1970’s with the breakthrough research carried out by scientists on the sequencing of DNA which lead to a greater understanding of naturally occurring organisms and the construction of parts now commonly referred to as “gene synthesis”.<br />
<br />
This led to Werner, Arber, Nathans, Hamilton and Smith receiving the Nobel Prize in 1978 for their work on “restrictive enzymes” which led to a toolkit where it was possible to create specific genetic modification in organisms which we know today as “Genetic Engineering” where segments of DNA could be taken from one organism and put into another. This resulted in the development of the Biotech Industry. <br />
<br />
The core notion is to produce “BioBricks” or Standard biological parts so that organisms can be easily reproduced and manipulated to perform special functions more efficiently or perhaps manipulated to fulfil entirely new functions. <br />
<br />
At this stage modelling allows synthetic biologists to better predict system behaviour, this is essential because precise and quantitative measurements of biological systems are important for improving the development and understanding of biology.<br />
<br />
= The Parliamentary Office on Science and Technology - Postnote on Synthetic Biology =<br />
<br />
The Parliamentary Office of Science and Technology produced a [http://www.parliament.uk/documents/post/postpn298.pdf Postnote] on Synthetic Biology. This helps put into context recent developments, the benefits and possible risks associated with synthetic biology together with the policy options for the development and governance of the research.<br />
<br />
Synthetic Biology could raise some concerns regarding ethics, bio security, bio safety, ownership of intellectual property and question the motivation of stakeholders. Concern is also been raised regarding the lack of proper regulation both within the Scientific Community and by governments Worldwide. <br />
<br />
= Synthetic Biology Dialogue Report =<br />
<br />
To address public opinion the Biotechnology and Biological Sciences Research Council (BBSRC) and the Engineering and Physical Sciences Research Council (EPSRC) initiated a project to develop a dialogue with the public regarding their concerns and aspirations for this emerging field. (These institutions invest over a billion pounds of public money annually in the engineering, physical and biosciences with a clear strategic focus on improving the quality of life in the UK)<br />
<br />
The findings of the [http://www.bbsrc.ac.uk/web/FILES/Reviews/1006-synthetic-biology-dialogue.pdf Synthetic Biology Dialogue Report] were published at a launch event in London on 14 June 2010.<br />
<br />
The report presents the findings of a series of public workshops and stakeholder interviews on the science and issues surrounding synthetic biology. The Project took place during 2009-2010 and was carried out by the TNS-BMRB, BBSRC, EPSRC with the support of the Department for Business, Innovation and Skills Sciencewise programme.<br />
<br />
The public can see the enormous potential of science but are concerned about the speed of progress, regulation and the risks of synthetic biology to health and the environment. <br />
In the future Research Councils will have to consider the technical and ethical issues connected to research and reflect on the motivation and leadership within the scientific community. Although International co-ordination of regulation was raised, in the context of technical advances in a global economy the challenges faced will make this difficult to implement. More information is available [http://www.epsrc.ac.uk/newsevents/news/2010/Pages/syntheticbiology.aspx here].<br />
<br />
A [http://www.bbsrc.ac.uk/web/FILES/Reviews/synbio_summary-report.pdf Synthetic Biology Overview Report]was published in February 2011 which gives a summary of the key findings.<br />
<br />
= Networks in Synthetic Biology =<br />
RoSBNet is one of seven [http://www.bbsrc.ac.uk/funding/opportunities/2007/synthetic-biology.aspx Synthetic Biology Networks] funded by four Research Councils, the EPSRC, the BBSRC, the AHRC and the ESRC. The aim of these networks is to establish communication and networking between researchers to share ideas, and encourage creative approaches to meet future challenges. This also allows the opportunity to build international multidisciplinary partnerships to attract research funding opportunities. The seven networks are:<br />
<br />
* [http://www.rosbnet.org/ RoSBNet From Robust Synthetic Biological Parts to Whole Systems: Theoretical, Practical and Ethical Challenges]<br />
* [http://www.bris.ac.uk/scn/ Synthetic Components Network: Towards Synthetic Biology From The Bottom Up]<br />
* [http://www.sppi-net.org/index.php SPPI - Net A Network for Synthetic Plant Products for Industry]<br />
* [http://www.synbiostandards.ac.uk/index.php Standards for the Design and Engineering of modular biological devices]<br />
* [http://www.ucl.ac.uk/synbion/network Synbion: The UCL Network in Synthetic Biology] <br />
* [http://www.sheffield.ac.uk/synbio/mates MATE’s: Microbial Applications To Tissue engineering, An Exemplar Synthetic Biology]<br />
* [http://www.synbiostandards.co.uk/resources.php?type=networks SynBiont: A Synthetic Biology Network for Modelling and Programming Cell-Chell Interactions]<br />
<br />
= The Synthetic Biology Special Interest Group =<br />
<br />
A [https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/ Synthetic Biology Special Interest Group (SynBio-SIG)] has been established as a link between the UK's research base and the relevant industrial communities. Its aim is to ensure that the UK's world-leading synthetic biology research can be translated and developed into commercial applications. <br />
<br />
= A Strategic Roadmap for Synthetic Biology in the UK =<br />
<br />
A [http://www.rcuk.ac.uk/documents/publications/SyntheticBiologyRoadmap.pdf UK roadmap for Synthetic Biology], produced by an independent panel of experts for the government's Department for Business Innovation and Skills, was published in July 2012 in order to develop 'a roadmap that defines the likely timeframe and actions required to establish a world leading Synthetic Biology industry within the UK.' <br />
<br />
== Core themes ==<br />
<br />
Five core themes emerged from this work. They were:<br />
* Foundational science and engineering: the need for sufficient capabilities for the UK to maintain a leading edge<br />
* Continuing responsible research and innovation: including the need for awareness, training and adherence to regulatory frameworks<br />
* Developing technology for commercial use<br />
* Applications and markets: identifying growth markets and developing applications<br />
* International cooperation<br />
<br />
== Key recommendations == <br />
<br />
To achieve these themes, five key recommendations were outlined:<br />
* Invest in a network of multidisciplinary centres to establish an outstanding UK synthetic biology resource.<br />
* Build a skilled, energised and well-funded UK-wide synthetic biology community [for example, via the Synthetic Biology Special Interest Group].<br />
* Invest to accelerate technology responsibly to market.<br />
* Assume a leading international role.<br />
* Establish a leadership council<br />
<br />
= Synthetic Biology Leadership Council =<br />
<br />
As part of the recommendations of the Synthetic Biology roadmap for the UK, the UK Government established a Synthetic Biology Leadership Council (SBLC) as a steering structure governance body that can assess progress, update recommendations and shape priorities for future implementation of the synthetic biology roadmap for the UK.<br />
<br />
The SBLC will provide a visible point for strategic coordination between the funding agencies, the research community, industry, government sponsors and other stakeholders, including societal and ethical representatives. <br />
<br />
[https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/synbio-leadership-council Click here for more details.]</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=What_is_Synthetic_Biology%3F&diff=1049What is Synthetic Biology?2014-01-04T16:15:19Z<p>Antonis: </p>
<hr />
<div>=Synthetic Biology – What’s it all about?= <br />
<br />
Synthetic Biology is a new research area which brings together Scientists and Engineers from a wide variety of backgrounds. Its aim is to develop new technologies that have the potential to contribute to resolving the many challenges facing the 21st Century society. <br />
<br />
The many possible applications cover several areas, and are perhaps best known for advances already made in the medical field by producing at low cost a precursor to the chemical compound artemisinin which is used in anti-malarian drugs. The benefits are far reaching and will eventually include energy and the environment: for example, in the future this could include making devices to produce fuel from waste; soaking up carbon from the atmosphere and locking it away to help towards reducing global warming; the synthesis of plastics not using oil as world reserves dwindle; developing devises to sense pollutants and aid dispersal to prevent environmental disasters, etc.<br />
<br />
The driving force is to improve and enhance the quality of daily life for millions in a positive way, but through a planned and responsible approach.<br />
<br />
= How does Synthetic Biology work? =<br />
<br />
Essentially Synthetic Biology involves the design and construction of new biological functions and systems not found in nature. It first began with the study of natural chemicals and the design of new chemical compounds in the field of synthetic chemistry which has been with us for the past 100 years. <br />
<br />
This was revolutionised in the 1970’s with the breakthrough research carried out by scientists on the sequencing of DNA which lead to a greater understanding of naturally occurring organisms and the construction of parts now commonly referred to as “gene synthesis”.<br />
<br />
This led to Werner, Arber, Nathans, Hamilton and Smith receiving the Nobel Prize in 1978 for their work on “restrictive enzymes” which led to a toolkit where it was possible to create specific genetic modification in organisms which we know today as “Genetic Engineering” where segments of DNA could be taken from one organism and put into another. This resulted in the development of the Biotech Industry. <br />
<br />
The core notion is to produce “BioBricks” or Standard biological parts so that organisms can be easily reproduced and manipulated to perform special functions more efficiently or perhaps manipulated to fulfil entirely new functions. <br />
<br />
At this stage modelling allows synthetic biologists to better predict system behaviour, this is essential because precise and quantitative measurements of biological systems are important for improving the development and understanding of biology.<br />
<br />
= The Parliamentary Office on Science and Technology - Postnote on Synthetic Biology =<br />
<br />
The Parliamentary Office of Science and Technology produced a [http://www.parliament.uk/documents/post/postpn298.pdf Postnote] on Synthetic Biology. This helps put into context recent developments, the benefits and possible risks associated with synthetic biology together with the policy options for the development and governance of the research.<br />
<br />
Synthetic Biology could raise some concerns regarding ethics, bio security, bio safety, ownership of intellectual property and question the motivation of stakeholders. Concern is also been raised regarding the lack of proper regulation both within the Scientific Community and by governments Worldwide. <br />
<br />
= Synthetic Biology Dialogue Report =<br />
<br />
To address public opinion the Biotechnology and Biological Sciences Research Council (BBSRC) and the Engineering and Physical Sciences Research Council (EPSRC) initiated a project to develop a dialogue with the public regarding their concerns and aspirations for this emerging field. (These institutions invest over a billion pounds of public money annually in the engineering, physical and biosciences with a clear strategic focus on improving the quality of life in the UK)<br />
<br />
The findings of the [http://www.bbsrc.ac.uk/web/FILES/Reviews/1006-synthetic-biology-dialogue.pdf Synthetic Biology Dialogue Report] were published at a launch event in London on 14 June 2010.<br />
<br />
The report presents the findings of a series of public workshops and stakeholder interviews on the science and issues surrounding synthetic biology. The Project took place during 2009-2010 and was carried out by the TNS-BMRB, BBSRC, EPSRC with the support of the Department for Business, Innovation and Skills Sciencewise programme.<br />
<br />
The public can see the enormous potential of science but are concerned about the speed of progress, regulation and the risks of synthetic biology to health and the environment. <br />
In the future Research Councils will have to consider the technical and ethical issues connected to research and reflect on the motivation and leadership within the scientific community. Although International co-ordination of regulation was raised, in the context of technical advances in a global economy the challenges faced will make this difficult to implement. More information is available [http://www.epsrc.ac.uk/newsevents/news/2010/Pages/syntheticbiology.aspx here].<br />
<br />
A [http://www.bbsrc.ac.uk/web/FILES/Reviews/synbio_summary-report.pdf Synthetic Biology Overview Report]was published in February 2011 which gives a summary of the key findings.<br />
<br />
= Networks in Synthetic Biology =<br />
RoSBNet is one of seven [http://www.bbsrc.ac.uk/funding/opportunities/2007/synthetic-biology.aspx Synthetic Biology Networks] funded by four Research Councils, the EPSRC, the BBSRC, the AHRC and the ESRC. The aim of these networks is to establish communication and networking between researchers to share ideas, and encourage creative approaches to meet future challenges. This also allows the opportunity to build international multidisciplinary partnerships to attract research funding opportunities. The seven networks are:<br />
<br />
* [http://www.rosbnet.org/ RoSBNet From Robust Synthetic Biological Parts to Whole Systems: Theoretical, Practical and Ethical Challenges]<br />
* [http://www.bris.ac.uk/scn/ Synthetic Components Network: Towards Synthetic Biology From The Bottom Up]<br />
* [http://www.sppi-net.org/index.php SPPI - Net A Network for Synthetic Plant Products for Industry]<br />
* [http://www.synbiostandards.ac.uk/index.php Standards for the Design and Engineering of modular biological devices]<br />
* [http://www.ucl.ac.uk/synbion/network Synbion: The UCL Network in Synthetic Biology] <br />
* [http://www.sheffield.ac.uk/synbio/mates MATE’s: Microbial Applications To Tissue engineering, An Exemplar Synthetic Biology]<br />
* [http://www.synbiostandards.co.uk/resources.php?type=networks SynBiont: A Synthetic Biology Network for Modelling and Programming Cell-Chell Interactions]<br />
<br />
= The Synthetic Biology Special Interest Group =<br />
<br />
A [https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/ Synthetic Biology Special Interest Group (SynBio-SIG)] has been established as a link between the UK's research base and the relevant industrial communities. Its aim is to ensure that the UK's world-leading synthetic biology research can be translated and developed into commercial applications. <br />
<br />
= A Strategic Roadmap for Synthetic Biology in the UK =<br />
<br />
A [http://www.rcuk.ac.uk/documents/publications/SyntheticBiologyRoadmap.pdf UK roadmap for Synthetic Biology], produced by an independent panel of experts for the government's Department for Business Innovation and Skills, was published in July 2012 in order to develop 'a roadmap that defines the likely timeframe and actions required to establish a world leading Synthetic Biology industry within the UK.' <br />
<br />
== Core themes ==<br />
<br />
Five core themes emerged from this work. They were:<br />
* Foundational science and engineering: the need for sufficient capabilities for the UK to maintain a leading edge<br />
* Continuing responsible research and innovation: including the need for awareness, training and adherence to regulatory frameworks<br />
* Developing technology for commercial use<br />
* Applications and markets: identifying growth markets and developing applications<br />
* International cooperation<br />
<br />
== Key recommendations == <br />
<br />
To achieve these themes, five key recommendations were outlined:<br />
* Invest in a network of multidisciplinary centres to establish an outstanding UK synthetic biology resource.<br />
* Build a skilled, energised and well-funded UK-wide synthetic biology community [for example, via the Synthetic Biology Special Interest Group].<br />
* Invest to accelerate technology responsibly to market.<br />
* Assume a leading international role.<br />
* Establish a leadership council</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=What_is_Synthetic_Biology%3F&diff=1048What is Synthetic Biology?2014-01-04T16:14:28Z<p>Antonis: </p>
<hr />
<div>=Synthetic Biology – What’s it all about?= <br />
<br />
Synthetic Biology is a new research area which brings together Scientists and Engineers from a wide variety of backgrounds. Its aim is to develop new technologies that have the potential to contribute to resolving the many challenges facing the 21st Century society. <br />
<br />
The many possible applications cover several areas, and are perhaps best known for advances already made in the medical field by producing at low cost a precursor to the chemical compound artemisinin which is used in anti-malarian drugs. The benefits are far reaching and will eventually include energy and the environment: for example, in the future this could include making devices to produce fuel from waste; soaking up carbon from the atmosphere and locking it away to help towards reducing global warming; the synthesis of plastics not using oil as world reserves dwindle; developing devises to sense pollutants and aid dispersal to prevent environmental disasters, etc.<br />
<br />
The driving force is to improve and enhance the quality of daily life for millions in a positive way, but through a planned and responsible approach.<br />
<br />
== How does Synthetic Biology work? ==<br />
<br />
Essentially Synthetic Biology involves the design and construction of new biological functions and systems not found in nature. It first began with the study of natural chemicals and the design of new chemical compounds in the field of synthetic chemistry which has been with us for the past 100 years. <br />
<br />
This was revolutionised in the 1970’s with the breakthrough research carried out by scientists on the sequencing of DNA which lead to a greater understanding of naturally occurring organisms and the construction of parts now commonly referred to as “gene synthesis”.<br />
<br />
This led to Werner, Arber, Nathans, Hamilton and Smith receiving the Nobel Prize in 1978 for their work on “restrictive enzymes” which led to a toolkit where it was possible to create specific genetic modification in organisms which we know today as “Genetic Engineering” where segments of DNA could be taken from one organism and put into another. This resulted in the development of the Biotech Industry. <br />
<br />
The core notion is to produce “BioBricks” or Standard biological parts so that organisms can be easily reproduced and manipulated to perform special functions more efficiently or perhaps manipulated to fulfil entirely new functions. <br />
<br />
At this stage modelling allows synthetic biologists to better predict system behaviour, this is essential because precise and quantitative measurements of biological systems are important for improving the development and understanding of biology.<br />
<br />
==The Parliamentary Office on Science and Technology - Postnote on Synthetic Biology ==<br />
<br />
The Parliamentary Office of Science and Technology produced a [http://www.parliament.uk/documents/post/postpn298.pdf Postnote] on Synthetic Biology. This helps put into context recent developments, the benefits and possible risks associated with synthetic biology together with the policy options for the development and governance of the research.<br />
<br />
Synthetic Biology could raise some concerns regarding ethics, bio security, bio safety, ownership of intellectual property and question the motivation of stakeholders. Concern is also been raised regarding the lack of proper regulation both within the Scientific Community and by governments Worldwide. <br />
<br />
== Synthetic Biology Dialogue Report ==<br />
<br />
To address public opinion the Biotechnology and Biological Sciences Research Council (BBSRC) and the Engineering and Physical Sciences Research Council (EPSRC) initiated a project to develop a dialogue with the public regarding their concerns and aspirations for this emerging field. (These institutions invest over a billion pounds of public money annually in the engineering, physical and biosciences with a clear strategic focus on improving the quality of life in the UK)<br />
<br />
The findings of the [http://www.bbsrc.ac.uk/web/FILES/Reviews/1006-synthetic-biology-dialogue.pdf Synthetic Biology Dialogue Report] were published at a launch event in London on 14 June 2010.<br />
<br />
The report presents the findings of a series of public workshops and stakeholder interviews on the science and issues surrounding synthetic biology. The Project took place during 2009-2010 and was carried out by the TNS-BMRB, BBSRC, EPSRC with the support of the Department for Business, Innovation and Skills Sciencewise programme.<br />
<br />
The public can see the enormous potential of science but are concerned about the speed of progress, regulation and the risks of synthetic biology to health and the environment. <br />
In the future Research Councils will have to consider the technical and ethical issues connected to research and reflect on the motivation and leadership within the scientific community. Although International co-ordination of regulation was raised, in the context of technical advances in a global economy the challenges faced will make this difficult to implement. More information is available [http://www.epsrc.ac.uk/newsevents/news/2010/Pages/syntheticbiology.aspx here].<br />
<br />
A [http://www.bbsrc.ac.uk/web/FILES/Reviews/synbio_summary-report.pdf Synthetic Biology Overview Report]was published in February 2011 which gives a summary of the key findings.<br />
<br />
== Networks in Synthetic Biology ==<br />
RoSBNet is one of seven [http://www.bbsrc.ac.uk/funding/opportunities/2007/synthetic-biology.aspx Synthetic Biology Networks] funded by four Research Councils, the EPSRC, the BBSRC, the AHRC and the ESRC. The aim of these networks is to establish communication and networking between researchers to share ideas, and encourage creative approaches to meet future challenges. This also allows the opportunity to build international multidisciplinary partnerships to attract research funding opportunities. The seven networks are:<br />
<br />
* [http://www.rosbnet.org/ RoSBNet From Robust Synthetic Biological Parts to Whole Systems: Theoretical, Practical and Ethical Challenges]<br />
* [http://www.bris.ac.uk/scn/ Synthetic Components Network: Towards Synthetic Biology From The Bottom Up]<br />
* [http://www.sppi-net.org/index.php SPPI - Net A Network for Synthetic Plant Products for Industry]<br />
* [http://www.synbiostandards.ac.uk/index.php Standards for the Design and Engineering of modular biological devices]<br />
* [http://www.ucl.ac.uk/synbion/network Synbion: The UCL Network in Synthetic Biology] <br />
* [http://www.sheffield.ac.uk/synbio/mates MATE’s: Microbial Applications To Tissue engineering, An Exemplar Synthetic Biology]<br />
* [http://www.synbiostandards.co.uk/resources.php?type=networks SynBiont: A Synthetic Biology Network for Modelling and Programming Cell-Chell Interactions]<br />
<br />
=== The Synthetic Biology Special Interest Group ===<br />
<br />
A [https://connect.innovateuk.org/web/synthetic-biology-special-interest-group/ Synthetic Biology Special Interest Group (SynBio-SIG)] has been established as a link between the UK's research base and the relevant industrial communities. Its aim is to ensure that the UK's world-leading synthetic biology research can be translated and developed into commercial applications. <br />
<br />
=== A Strategic Roadmap for Synthetic Biology in the UK ===<br />
<br />
A [http://www.rcuk.ac.uk/documents/publications/SyntheticBiologyRoadmap.pdf UK roadmap for Synthetic Biology], produced by an independent panel of experts for the government's Department for Business Innovation and Skills, was published in July 2012 in order to develop 'a roadmap that defines the likely timeframe and actions required to establish a world leading Synthetic Biology industry within the UK.' <br />
<br />
== Core themes ==<br />
<br />
Five core themes emerged from this work. They were:<br />
* Foundational science and engineering: the need for sufficient capabilities for the UK to maintain a leading edge<br />
* Continuing responsible research and innovation: including the need for awareness, training and adherence to regulatory frameworks<br />
* Developing technology for commercial use<br />
* Applications and markets: identifying growth markets and developing applications<br />
* International cooperation<br />
<br />
== Key recommendations == <br />
<br />
To achieve these themes, five key recommendations were outlined:<br />
* Invest in a network of multidisciplinary centres to establish an outstanding UK synthetic biology resource.<br />
* Build a skilled, energised and well-funded UK-wide synthetic biology community [for example, via the Synthetic Biology Special Interest Group].<br />
* Invest to accelerate technology responsibly to market.<br />
* Assume a leading international role.<br />
* Establish a leadership council</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1047Welcome to RoSBNet wiki2013-12-26T15:30:20Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
UK - [http://www.sebiology.org/meetings/synthetic_biology/overview.html Synthetic Biology 2014]<br />
<br />
- 8-10 January 2014.<br />
<br />
- Society of Experimental Biology, Charles Darwin House, London.<br />
<br />
<br />
USA - [http://w-qbio.org Winter Q-bio meeting]<br />
<br />
- 17-20 February 2014.<br />
<br />
- Hawaii, USA.<br />
<br />
<br />
USA - [http://ibe.org/meetings-and-events.html Institute of Biological Engineering 2014 Annual Conference]<br />
<br />
- 6-8 March 2014.<br />
<br />
- Lexington, KY, USA.<br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 3-4 June 2014.<br />
<br />
- Boston, MA, USA.<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
Spain - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
Australia - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community.<br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1046Welcome to RoSBNet wiki2013-12-26T15:29:34Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
UK - [http://www.sebiology.org/meetings/synthetic_biology/overview.html Synthetic Biology 2014]<br />
<br />
- 8-10 January 2014.<br />
<br />
- Society of Experimental Biology, Charles Darwin House, London.<br />
<br />
<br />
USA - [w-qbio.org Winter Q-bio meeting]<br />
<br />
- 17-20 February 2014.<br />
<br />
- Hawaii, USA.<br />
<br />
<br />
USA - [http://ibe.org/meetings-and-events.html Institute of Biological Engineering 2014 Annual Conference]<br />
<br />
- 6-8 March 2014.<br />
<br />
- Lexington, KY, USA.<br />
<br />
<br />
USA - [http://www.terrapinn.com/conference/synbio/index.stm Synbio 2014]<br />
<br />
- 3-4 June 2014.<br />
<br />
- Boston, MA, USA.<br />
<br />
<br />
USA - [http://integrativebiology2014.conferenceseries.net/index.php 2nd International Conference on Integrative Biology Summit]<br />
<br />
- 4-5 August 2014.<br />
<br />
- Chicago, IL, USA.<br />
<br />
<br />
USA - [http://syntheticbio.esf.org/ Synthetic Biology on Antibiotic Production]<br />
<br />
- 30 August-4 September 2014.<br />
<br />
- Sant Feliu de Guixols, Spain.<br />
<br />
<br />
USA - [http://www.icsb14.com/ 15th International Conference on Systems Biology]<br />
<br />
- 14-18 September 2014.<br />
<br />
- Melbourne, Australia. <br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community.<br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1044Welcome to RoSBNet wiki2013-08-16T17:28:10Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
<br />
Germany - [http://www.synmikro.com/de/aktuelles/termine/synmarburg-summer-school-2013.html SYNMarburg Summer School 2013]<br />
<br />
- 19-30 August 2013<br />
<br />
- Philipps-Universität Marburg and Max Planck Institute for Terrestrial Microbiology, Germany.<br />
<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community.<br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1043Welcome to RoSBNet wiki2013-06-01T16:18:21Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
USA - [http://www.grc.org/programs.aspx?year=2013&program=synthbio (Re-)constructing and Re-programming Life] <br />
<br />
- 9-14 June 2013<br />
<br />
- Mount Snow Resort, West Dover, VT<br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
Germany - [http://www.synmikro.com/de/aktuelles/termine/synmarburg-summer-school-2013.html SYNMarburg Summer School 2013]<br />
<br />
- 19-30 August 2013<br />
<br />
- Philipps-Universität Marburg and Max Planck Institute for Terrestrial Microbiology, Germany.<br />
<br />
<br />
<br />
USA - [http://meetings.cshl.edu/courses/2013/c-synbio13.shtml 2013 CSHL course in Synthetic Biology]<br />
<br />
- 30 July - 12 August 2013<br />
<br />
- Cold Spring Harbor, NY<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community.<br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1042Welcome to RoSBNet wiki2013-05-14T11:50:03Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community.<br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1039Welcome to RoSBNet wiki2013-01-12T12:29:53Z<p>Antonis: </p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<!--<br />
<center><br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
<br />
US - [http://www.nimbios.org/workshops/WS_ss_micro.html NIMBioS Investigative Workshop on Systems and Synthetic Microbiology]<br />
<br />
- March 11-13, 2013 <br><br />
<br />
- NIMBioS at the University of Tennessee, Knoxville<br />
<br />
<br />
US - [http://www.ibsi.gatech.edu/FSSB13 Frontiers in Systems and Synthetic Biology]<br />
<br />
- March 20-24, 2013 <br><br />
<br />
- Atlanta, Georgia. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community.<br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1038Welcome to RoSBNet wiki2013-01-12T12:29:33Z<p>Antonis: </p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<!--<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community. </span>]<br><br />
</center><br />
--><br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
<br />
US - [http://www.nimbios.org/workshops/WS_ss_micro.html NIMBioS Investigative Workshop on Systems and Synthetic Microbiology]<br />
<br />
- March 11-13, 2013 <br><br />
<br />
- NIMBioS at the University of Tennessee, Knoxville<br />
<br />
<br />
US - [http://www.ibsi.gatech.edu/FSSB13 Frontiers in Systems and Synthetic Biology]<br />
<br />
- March 20-24, 2013 <br><br />
<br />
- Atlanta, Georgia. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
<br />
The project that supports RoSBNet has now reached its end but the Wiki will continue to serve as a link between members and the community.<br />
<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1037Welcome to RoSBNet wiki2012-12-05T15:35:18Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
<br />
US - [http://www.nimbios.org/workshops/WS_ss_micro.html NIMBioS Investigative Workshop on Systems and Synthetic Microbiology]<br />
<br />
- March 11-13, 2013 <br><br />
<br />
- NIMBioS at the University of Tennessee, Knoxville<br />
<br />
<br />
US - [http://www.ibsi.gatech.edu/FSSB13 Frontiers in Systems and Synthetic Biology]<br />
<br />
- March 20-24, 2013 <br><br />
<br />
- Atlanta, Georgia. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1036Welcome to RoSBNet wiki2012-12-05T11:25:48Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
<br />
US - [http://www.ibsi.gatech.edu/FSSB13 Frontiers in Systems and Synthetic Biology]<br />
<br />
- March 20-24, 2013 <br><br />
<br />
- Atlanta, Georgia. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1035Welcome to RoSBNet wiki2012-12-05T11:25:41Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
US - [http://www.ibsi.gatech.edu/FSSB13 Frontiers in Systems and Synthetic Biology]<br />
<br />
- March 20-24, 2013 <br><br />
<br />
- Atlanta, Georgia. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1034Welcome to RoSBNet wiki2012-11-05T15:33:03Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
China - [http://csh-asia.org/SYNTHESI12.html Cold Spring Harbor Asia - Synthetic Biology]<br />
<br />
- 26-30 November 2012 <br><br />
<br />
- Suzhou, China. <br><br />
<br />
<br />
France - [http://www.genopole.fr/newsletter/sdvs/2012_save_the_date.html Synthetic Biology, Science and Society]<br />
<br />
- 4 December 2012 <br><br />
<br />
- Paris, France. <br><br />
<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1033Welcome to RoSBNet wiki2012-10-20T15:12:13Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
US - [http://synbiobeta.com/ SYNBIOBETA, The Synthetic Biology Startup Ecosystem]<br />
<br />
- November 4, 2012 <br><br />
<br />
- Silicon Valley, US. <br><br />
<br />
<br />
China - [http://csh-asia.org/SYNTHESI12.html Cold Spring Harbor Asia - Synthetic Biology]<br />
<br />
- 26-30 November 2012 <br><br />
<br />
- Suzhou, China. <br><br />
<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1032Welcome to RoSBNet wiki2012-09-19T12:17:51Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
UK -[http://www.cambridgebiodesign.org/tech/index.html Cambridge BioDesign TechEvent 2012]<br />
<br />
- 25 September 2012 <br><br />
<br />
- Cambridge, UK. <br><br />
<br />
<br />
Spain - [[Media:Posterb.pdf | An International Workshop on Systems and Synthetic Biology ]]<br />
<br />
- 16-20 October, 2012 <br><br />
<br />
- Mallorca, Spain. <br><br />
<br />
<br />
US - [http://synbiobeta.com/ SYNBIOBETA, The Synthetic Biology Startup Ecosystem]<br />
<br />
- November 4, 2012 <br><br />
<br />
- Silicon Valley, US. <br><br />
<br />
<br />
China - [http://csh-asia.org/SYNTHESI12.html Cold Spring Harbor Asia - Synthetic Biology]<br />
<br />
- 26-30 November 2012 <br><br />
<br />
- Suzhou, China. <br><br />
<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1028Welcome to RoSBNet wiki2012-09-03T20:51:51Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
Switzerland -[http://www.eccb12.org/home 11th European Conference on Computational Biology]<br />
<br />
- 9-12 September 2012 <br><br />
<br />
- Basel, Switzerland. <br><br />
<br />
<br />
Spain - [[Media:Posterb.pdf | An International Workshop on Systems and Synthetic Biology ]]<br />
<br />
- 16-20 October, 2012 <br><br />
<br />
- Mallorca, Spain. <br><br />
<br />
<br />
China - [http://csh-asia.org/SYNTHESI12.html Cold Spring Harbor Asia - Synthetic Biology]<br />
<br />
- 26-30 November 2012 <br><br />
<br />
- Suzhou, China. <br><br />
<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1027Welcome to RoSBNet wiki2012-08-16T11:38:47Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
Canada - [http://www.icsb2012toronto.com/ ICSB 2012]<br />
<br />
- 13-29 August 2012 <br><br />
<br />
- Toronto, Canada. <br><br />
<br />
<br />
Switzerland -[http://www.eccb12.org/home 11th European Conference on Computational Biology]<br />
<br />
- 9-12 September 2012 <br><br />
<br />
- Basel, Switzerland. <br><br />
<br />
<br />
Spain - [[Media:Posterb.pdf | An International Workshop on Systems and Synthetic Biology ]]<br />
<br />
- 16-20 October, 2012 <br><br />
<br />
- Mallorca, Spain. <br><br />
<br />
<br />
China - [http://csh-asia.org/SYNTHESI12.html Cold Spring Harbor Asia - Synthetic Biology]<br />
<br />
- 26-30 November 2012 <br><br />
<br />
- Suzhou, China. <br><br />
<br />
<br />
US - [http://w-qbio.org/ WINTER Q-BIO MEETING]<br />
<br />
- February 18-21, 2013 <br><br />
<br />
- Hawaiian Islands. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Member_List&diff=1021Member List2012-07-11T14:44:37Z<p>Antonis: /* Researchers from the Ethical, Legal and Social Sciences */</p>
<hr />
<div>= RoSBNet Members =<br />
<br />
Below you will find a list of RoSBNet members, with links to their websites for more information.<br />
<br />
== Engineering/Mathematics Researchers == <br />
{| border="1"<br />
! Member !! Affiliation !! Research Interests !!<br />
<br />
|-<br />
| [http://sysos.eng.ox.ac.uk/control/sysos/index.php/User:Antonis Antonis Papachristodoulou] || University of Oxford || Systems and synthetic biology, nonlinear systems, automatic control systems, synchronization, complex networks<br />
|-<br />
| [http://www.ist.uni-stuttgart.de/allgower/allgower.shtml Frank Allgower] || Institute for Systems Theory and Automatic Control, University of Stuttgart || Automatic control, systems biology<br />
|-<br />
|[http://www3.imperial.ac.uk/people/m.barahona Mauricio Barahona] || Imperial College London || Applied mathematics in biological, physical and engineering systems<br />
|-<br />
| [http://www.eee.strath.ac.uk/~hongyue/ Hong Yue] || University of Strathclyde || Modelling and system analysis of biological networks; optimal/robust experimental design; Process control <br />
|-<br />
| [http://www.eee.manchester.ac.uk/aboutus/staff/show.html?ea=William.Heath William Heath] || University of Manchester || System Identification: in particular identification of signals and dynamic models associated with biological homeostasis<br />
|-<br />
| [http://biology.st-andrews.ac.uk/vannesmithlab/ Anne Smith] || University of St Andrews || Complex biological networks (molecular, neuronal, ecological), network evolution<br />
|-<br />
| [http://www.rdg.ac.uk/icmr/about/staff/icmr-m-tindall.asp Marcus Tindall] || University of Reading || Mathematical modelling, multi-scale modelling, multicellular systems biology, bacterial chemotaxis , non-linear ordinary and partial differential equations<br />
|-<br />
| [http://www.montefiore.ulg.ac.be/~bullinger/ Eric Bullinger] || Université de Liège || Systems Biology, from data analysis over modelling to model analysis as well as the development of system theoretical methodologies<br />
|-<br />
| [http://www.gla.ac.uk/departments/aerospace/staff/academicstaff/jongraekim Jongrae Kim] || University of Glasgow || Stochastic dynamics; System identification; Robustness analysis; Large-scale network analysis<br />
|-<br />
| [http://control.ee.ethz.ch/~auguste/ Elias August] || Swiss Federal Institute of Technology || Systems biology<br />
|-<br />
| [http://www.sbs.ox.ac.uk/faculty/Reed-Tsochas+Felix/ Felix Reed-Tsochas] || University of Oxford || <br />
|-<br />
| [http://www.stats.ox.ac.uk/people/academic_staff/jotun_hein Jotun Hein] || University of Oxford || Bioinformatics<br />
|-<br />
| [http://sysos.eng.ox.ac.uk/control/sysos/index.php/User:James_Anderson James Anderson] || University of Oxford || Control and dynamical systems, systems biology, synthetic biology<br />
|-<br />
| [http://www.eng.ox.ac.uk/samp/people.html Patrick McSharry] || University of Oxford || Signal processing, systems biology, complex adaptive systems, operations research and forecasting<br />
|-<br />
| [http://www.ist.uni-stuttgart.de/~waldherr/ Steffen Waldherr] || Institute for Systems Theory and Automatic Control Universität Stuttgart || Applications of approaches from control engineering and dynamical systems theory to systems biology and biological networks<br />
|-<br />
| [http://www3.imperial.ac.uk/people/r.tanaka Reiko Tanaka] || Imperial College London || Biological control, systems biology<br />
|-<br />
| [http://www.comlab.ox.ac.uk/people/Jonathan.Whiteley/ Jonathan Whiteley] || University of Oxford || Mathematical modelling and scientific computing related to multiscale, multiphysics problems arising in physiology and biology<br />
|-<br />
| [http://www.physics.ox.ac.uk/users/kapanidis/ Achillefs Kapanidis] || University of Oxford || Single-molecule studies of DNA-processing biomachines<br />
|-<br />
|[http://www.staff.ncl.ac.uk/d.j.wilkinson/ Darren Wilkinson] || Newcastle University || Applications of Bayesian statistics to a variety of problems in Molecular biology, Bioinformatics and Systems Biology<br />
|-<br />
| [http://www.comlab.ox.ac.uk/people/David.Gavaghan/ David Gavaghan] || University of Oxford || Computational biology<br />
|-<br />
| [http://emps.exeter.ac.uk/staff/dgb208 Declan Bates] || University of Exeter || Robustness and feedback control in cellular and physiological systems <br />
|-<br />
| [http://www-control.eng.cam.ac.uk/~jmg77/ Jorge Goncalves] || University of Cambridge || Systems Biology: modelling, analysis, and control of biological systems like circadian rhythms and gene regulatory networks.<br />
|-<br />
| [http://www.mit.edu/~ddv/ Domitilla del Vecchio] || MIT || Control and dynamical systems, biomolecular networks<br />
|-<br />
| [http://biochemistry.ucsf.edu/labs/elsamad/people/Hana_El_Samad/hana_el_samad.html Hana El-Samad] || University of California, San Francisco || Interface between biology, mathematics, dynamical systems, and control theory<br />
|-<br />
| [http://www.bionanotechnology.ox.ac.uk/index.php?option=com_content&task=view&id=24&Itemid=50 John Ryan] || University of Oxford ||Molecular motors, membrane proteins, single-molecule electronics and photonics<br />
|-<br />
| [http://www.engineering.ucsb.edu/~khammash/ Mustafa Khammash ] || University of California, Santa Barbara || Control theory and its applications to engineering and to biological systems<br />
|-<br />
| [http://people.maths.ox.ac.uk/~maini/ Philip Maini] || University of Oxford || Mathematical and computational modelling of temporal and spatiotemporal phenomena in a number of areas in the life sciences, including developmental biology, wound healing, cancer biology and bacterial chemotaxis<br />
|- <br />
| [http://www2.imperial.ac.uk/~nsjones/ Nick Jones] || Imperial College London || Cellular fluctuations and cellular energy variability, Principles of Natural networks<br />
|-<br />
| [http://www.eng.ox.ac.uk/control/peopleSD.shtml Steve Duncan] || University of Oxford || Control theory, biological systems, epidemiology<br />
|-<br />
| [http://www3.imperial.ac.uk/people/g.stan Guy-Bart Stan] || Imperial College London || Nonlinear dynamical systems and control, complex networks, synthetic biology, systems biology<br />
|-<br />
| [http://melykuti.web.elte.hu/index.htm Bence Melykuti] || University of California, Santa Barbara || The interfaces of mathematical (esp. probabilistic) modelling, stochastic processes, control theory, systems biology, operations research<br />
|-<br />
| [http://www-control.eng.cam.ac.uk/~aoh21/ Abdullah Hamadeh] || University of Waterloo || Modelling and analysis of nonlinear dynamical systems with applications to automatic control, process control and systems biology<br />
|-<br />
| [http://www.eng.ox.ac.uk/~stcman/people.shtml Edward Hancock] || University of Oxford || Nonlinear dynamical systems, systems biology<br />
|-<br />
| [http://www.st-hildas.ox.ac.uk/index.php/fellowsandlecturers/alubansky.html Alex Lubansky] || University of Oxford || Microfluidics, Rheology, Synthetic Biology<br />
|-<br />
|[http://www3.imperial.ac.uk/people/natalja.strelkowa06 Natalja Strelkowa] || Imperial College London || Stochastic analysis of gene regulatory networks and applications of control theory and theoretical aspects of population dynamical models <br />
|-<br />
| [http://www.multidisciplinary.soton.ac.uk/profile/ajc6/#information Andrew Chipperfield] || University of Southampton || Control systems engineering, biomedical modelling, signal processing <br />
|-<br />
| [http://people.exeter.ac.uk/oss203/ Orkun Soyer] || University of Exeter || Evolutionary systems biology, synthetic biology, signalling networks, metabolic networks, bacterial communities<br />
|-<br />
| [http://www.enm.bris.ac.uk/anm/staff/enmdb/home.html Mario Di Bernardo] || University of Bristol || Analysis, synchronization and control of complex networks, systems and synthetic Biology <br />
|-<br />
| [http://users.ox.ac.uk/~dpag0022/index.htm Eric Werner] || University of Oxford || <br />
|-<br />
| [http://mpf.biol.vt.edu/lab_website/people/Tongli_Zhang/ Tongli Zhang] || University of Oxford ||Modelling signal transduction pathways in mammalian cells<br />
|-<br />
| [http://www.montefiore.ulg.ac.be/~sepulch/ Rodolphe Sepulchre] || Université de Liège || Nonlinear control and optimization<br />
|}<br />
<br />
== Biology/Biochemistry Researchers == <br />
<br />
{| border="1"<br />
! Member !! Affiliation !! Research Interests !!<br />
<br />
|-<br />
| [http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=565 Judy Armitage] || University of Oxford || Bacterial networks and protein dynamics<br />
|-<br />
| [http://www.abdn.ac.uk/ims/staff/details.php?id=i.stansfield Ian Stansfield] || University of Aberdeen || The mechanism of protein synthesis in eukaryote cells, and in the control of gene expression at the level of mRNA translation, both using the yeast Saccharomyces as a model system<br />
|-<br />
| [http://www.brookes.ac.uk/res/experts/profiles/david_fell David Fell] || Oxford Brookes University || General principles governing the organization, regulation and control of metabolism<br />
|-<br />
| [http://www.plantsci.cam.ac.uk/research/alexwebb.html Alex Webb] || University of Cambridge || The physiological benefits of the circadian clock and the signalling mechanisms by which the circadian clock regulates cell physiology<br />
|-<br />
| [http://swainlab.bio.ed.ac.uk/details.php Peter Swain] || University of Edinburgh || Systems biology<br />
|-<br />
| [http://www.eng.ox.ac.uk/~cheit/ Ian Thompson] || University of Oxford || <br />
|-<br />
| [http://dps.plants.ox.ac.uk/plants/Staff/LeeSweetlove.aspx Lee Sweetlove] ||University of Oxford ||Regulation and engineering of the plant metabolic network<br />
|-<br />
| [http://www.lincoln.ox.ac.uk/content/view/832/40/ Mark Roberts] || University of Oxford/BBSRC || Biological signalling circuits, bacterial transcription<br />
|-<br />
| [http://www.pmb.ox.ac.uk/Fellows_Staff/Fellow_and_Staff_Profiles.php?profile=146 Steve Porter]|| University of Exeter|| Chemosensory signal transduction pathway in the photosynthetic bacterium, Rhodobacter sphaeroides <br />
|-<br />
| [http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php/User:MarkChang Yo-Cheng (Mark) Chang] ||University of Oxford || Systems and synthetic biology<br />
|-<br />
| [http://waterfall.union.edu/Staff_Directory/Union/Electrical__Computer_Engineering/Hooshangi_Sara_.php Sara Hooshangi]|| Union College, NY ||<br />
|-<br />
| [http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=593 Bela Novak] || University of Oxford ||<br />
|-<br />
| [http://www.sysbio.ox.ac.uk/People/GW.html George Wadhams] || University of Oxford || Quantitative analysis of bacterial signalling pathways. Rewiring two component signal transduction pathways. Manipulation of protein-protein interactions within signalling pathways. The effect of host cell choice on the input-output characteristics of biological pathways<br />
|-<br />
|[http://sbcb.bioch.ox.ac.uk/sansom.php Mark Sansom]|| University of Oxford ||<br />
|-<br />
|[http://www.sheffield.ac.uk/civil/staff/academic/wh.html Wei Huang] || University of Sheffield || Single cell Raman tweezers technology (e.g. study genetic functions of non-culturable microorganisms in ecosystem). Microbial evolution (e.g. the role of gene transformation in evolution). Synthetic biology (e.g. gene trapping & screening, biosensors and bioenergy) <br />
|-<br />
|[http://www2.le.ac.uk/departments/engineering/ William Bryant] ||University of Leicester || <br />
|-<br />
|[http://www.shef.ac.uk/materials/staff/claeyssens.html Frederik Claeyssens]|| University of Sheffield ||<br />
|-<br />
|[http://www.cs.ncl.ac.uk/people/j.s.hallinan Jennifer Hallinan] ||Newcastle University||Complex Systems and analysis of biological networks<br />
|-<br />
| [http://www3.imperial.ac.uk/people/k.polizzi Karen Polizzi] || Imperial College London || Biopharmaceutical processing, neurodegeneration and ageing, tools for synthetic biology<br />
|-<br />
|[http://www2.warwick.ac.uk/fac/sci/whri/about/staff/kdenby/ Katherine Denby] || University of Warwick||<br />
|-<br />
|[http://www.ceas.manchester.ac.uk/aboutus/staff/show.html?ea=hans.westerhoff Hans Westerhoff] || University of Manchester ||Integrative systems biology<br />
|-<br />
| [http://www.eda.kent.ac.uk/school/staff_detail.aspx?id=330 Najl Valeyev] || University of Kent ||<br />
|-<br />
| [http://www.dpag.ox.ac.uk/research/cardiac_science/peter_robbins/robbins_members Nayia Petousi]|| University of Oxford ||<br />
|-<br />
| [http://www.mib.manchester.ac.uk/postgraduate/DTC/ Victoria Jackson] || University of Manchester || Integrative Systems Biology <br />
|}<br />
<br />
<br />
<br />
<br />
<br />
<br />
== Researchers from the Ethical, Legal and Social Sciences == <br />
<br />
{| border="1"<br />
! Member !! Affiliation !! Research Interests !!<br />
<br />
|-<br />
| [http://web.comlab.ox.ac.uk/Annamaria.Carusi/ Annamaria Carusi] || University of Oxford || Philosophical issues relating to synthetic biology; ethics, science and technology studies<br />
|-<br />
| [http://www.sbs.ox.ac.uk/insis/people/sugden+chris.htm Chris Sugden] || University of Oxford || Contemporary ideas of novelty and innovation<br />
|-<br />
| [http://www.ethox.org.uk/people/michael-parker Michael Parker] || University of Oxford ||<br />
|-<br />
| [http://people.bath.ac.uk/ak280/ Alexander Kelle] || University of Bath ||<br />
|-<br />
| [http://www.ifom-ieo-campus.it/research/boniolocv.php Giovanni Boniolo]|| European Institute of Oncology||<br />
|-<br />
| [http://www.practicalethics.ox.ac.uk/nstaff.htm Julian Savulescu] || University of Oxford ||<br />
|-<br />
| [http://www.philosophy.ox.ac.uk/members/marianne_talbot Marianne Talbot] || University of Oxford || <br />
|-<br />
| [http://www.bep.ox.ac.uk/our%20people.html Mark Sheehan] || University of Oxford || Research ethics, ethics of emerging technologies, ethics of resource allocation, the ethics and justification of public engagement, ethics and social science methodology<br />
|-<br />
| [http://www.neuroethics.ox.ac.uk/node/19 Steve Clarke] || University of Oxford ||<br />
|-<br />
| [http://www.ethox.org.uk/people/jane-kaye Jane Kaye] ||University of Oxford ||The role of law in the global regulation of innovative technologies in medicine, with particular focus on biobanks and standardisation<br />
|-<br />
| [http://www.practicalethics.ox.ac.uk/nstaff.htm#staff Thomas Douglas] || University of Oxford || The ethics of enhancing or modifying moral capacities, the nature of moral improvement, and the ethics of producing and disseminating dangerous knowledge<br />
|-<br />
| [http://helex.medsci.ox.ac.uk/staff/researchers/liam-curren Liam Curren] || ||<br />
|-<br />
| [http://www.sussex.ac.uk/Units/spru/hsp/People/James%20Revill.html James Revill] || University of Sussex ||<br />
|}</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1020Welcome to RoSBNet wiki2012-07-11T14:43:10Z<p>Antonis: /* RoSBNet will network in 3 ways: */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
Canada - [http://www.icsb2012toronto.com/ ICSB 2012]<br />
<br />
- 13-29 August 2012 <br><br />
<br />
- Toronto, Canada. <br><br />
<br />
<br />
Switzerland -[http://www.eccb12.org/home 11th European Conference on Computational Biology]<br />
<br />
- 9-12 September 2012 <br><br />
<br />
- Basel, Switzerland <br><br />
<br />
<br />
Spain - [[Media:Posterb.pdf | An International Workshop on Systems and Synthetic Biology ]]<br />
<br />
- 16-20 October, 2012 <br><br />
<br />
- Mallorca, Spain. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet networks in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] that were held in Oxford during the project duration.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1019Welcome to RoSBNet wiki2012-07-11T14:42:32Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
Canada - [http://www.icsb2012toronto.com/ ICSB 2012]<br />
<br />
- 13-29 August 2012 <br><br />
<br />
- Toronto, Canada. <br><br />
<br />
<br />
Switzerland -[http://www.eccb12.org/home 11th European Conference on Computational Biology]<br />
<br />
- 9-12 September 2012 <br><br />
<br />
- Basel, Switzerland <br><br />
<br />
<br />
Spain - [[Media:Posterb.pdf | An International Workshop on Systems and Synthetic Biology ]]<br />
<br />
- 16-20 October, 2012 <br><br />
<br />
- Mallorca, Spain. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet will network in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] with the next hosted on 20th-22nd July 2011 in Oxford.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1018Welcome to RoSBNet wiki2012-07-11T14:42:22Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
Canada - [http://www.icsb2012toronto.com/ ICSB 2012]<br />
<br />
- 13-29 August 2012 <br><br />
<br />
- Toronto, Canada. <br><br />
<br />
<br />
Switzerland -[http://www.eccb12.org/home 11th European Conference on Computational Biology]<br />
<br />
- 9-12 September 2012 <br><br />
<br />
- Basel, Switzerland <br><br />
<br />
<br />
Spain - [[Media:Posterb.pdf | An International Workshop on Systems and Synthetic Biology ]]<br />
<br />
- 16-20 October, 2012 <br><br />
<br />
- Mallorca, Spain. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK.<br />
<br />
<br />
<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet will network in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] with the next hosted on 20th-22nd July 2011 in Oxford.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1009Welcome to RoSBNet wiki2012-03-26T11:00:48Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
France - [http://www-rocq.inria.fr/~batt/design_opt_control/home.html Design, optimization and control in systems and synthetic biology]<br />
<br />
-11-12 June 2012<br><br />
<br />
-Paris, France<br />
<br />
<br />
UK - [http://engeneious.chem.ox.ac.uk/ enGENEious]<br />
<br />
- 25-26 June 2012 <br><br />
<br />
- Oxford, UK. <br><br />
<br />
<br />
Canada - [http://www.icsb2012toronto.com/ ICSB 2012]<br />
<br />
- 13-29 August 2012 <br><br />
<br />
- Toronto, Canada. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK<br />
<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet will network in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] with the next hosted on 20th-22nd July 2011 in Oxford.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=1007Welcome to RoSBNet wiki2012-03-20T17:02:24Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
UK - [http://engeneious.chem.ox.ac.uk/ enGENEious]<br />
<br />
- 25-26 June 2012 <br><br />
<br />
- Oxford, UK. <br><br />
<br />
<br />
Canada - [http://www.icsb2012toronto.com/ ICSB 2012]<br />
<br />
- 13-29 August 2012 <br><br />
<br />
- Toronto, Canada. <br><br />
<br />
<br />
UK - [http://sb6.biobricks.org/ SB6.0]<br />
<br />
- 9-11 July 2013<br />
<br />
- London, UK<br />
<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet will network in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] with the next hosted on 20th-22nd July 2011 in Oxford.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=992Welcome to RoSBNet wiki2011-12-31T14:56:05Z<p>Antonis: </p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Even if the project that supports RoSBNet has now reached its end, the Wiki will continue to serve as a link between members and the community. Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
UK - [http://engeneious.chem.ox.ac.uk/ enGENEious]<br />
<br />
- 25-26 June 2012 <br><br />
<br />
- Oxford, UK.<br />
<br />
<br />
Canada - [http://www.icsb2012toronto.com/ ICSB 2012]<br />
<br />
- 13-29 August 2012 <br><br />
<br />
- Toronto, Canada.<br />
<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet will network in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] with the next hosted on 20th-22nd July 2011 in Oxford.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=991Welcome to RoSBNet wiki2011-12-31T14:43:49Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
UK - [http://engeneious.chem.ox.ac.uk/ enGENEious]<br />
<br />
- 25-26 June 2012 <br><br />
<br />
- Oxford, UK.<br />
<br />
<br />
Canada - [http://www.icsb2012toronto.com/ ICSB 2012]<br />
<br />
- 13-29 August 2012 <br><br />
<br />
- Toronto, Canada.<br />
<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet will network in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] with the next hosted on 20th-22nd July 2011 in Oxford.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=990Welcome to RoSBNet wiki2011-12-31T14:43:36Z<p>Antonis: /* Upcoming Events */</p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
UK - [http://engeneious.chem.ox.ac.uk/ enGENEious]<br />
<br />
- 25-26 June 2012 <br><br />
<br />
- Oxford, UK.<br />
<br />
Canada - [http://www.icsb2012toronto.com/ ICSB 2012]<br />
<br />
- 13-29 August 2012 <br><br />
<br />
- Toronto, Canada.<br />
<br />
UK - [http://www.biosysbio.com/ BioSysBio 2012]<br />
<br />
- TBA <br><br />
<br />
- Cambridge, UK.<br />
<br />
}}<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet will network in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] with the next hosted on 20th-22nd July 2011 in Oxford.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=989Welcome to RoSBNet wiki2011-10-21T11:41:24Z<p>Antonis: </p>
<hr />
<div><center><br />
[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
<br><br />
</center><br />
<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
</center><br />
<br />
== Upcoming Events ==<br />
{{scrollable<br />
|height=200<br />
|content=<br />
<br />
China - [http://www.csh-asia.org/design11.html 2011 CSHA Symposium "Design and Synthesis of Biological Systems"]<br />
<br />
- 7-11 November 2011 <br><br />
<br />
- Suzhou, China.<br />
<br />
}}<br />
<br />
<br />
<br />
== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet will network in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] with the next hosted on 20th-22nd July 2011 in Oxford.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
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__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Welcome_to_RoSBNet_wiki&diff=988Welcome to RoSBNet wiki2011-08-29T12:22:17Z<p>Antonis: </p>
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[[Image:RoSBlogos.jpg|thumb|center|400xpx]]<br />
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<center><br />
<br />
[http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php?title=Special:Userlogin&type=signup <span style="color:#FF0000; font-size: 200%;"> ''Please sign up to create a login in order to add information to the Wiki'' </span>]<br><br />
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== Upcoming Events ==<br />
{{scrollable<br />
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Spain - [http://www.esf.org/index.php?id=7241 ESF-EMBO Research Conference "Synthetic Biology of Antibiotic Production"]<br />
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- 2-7 October 2011 <br><br />
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- Sant Feliu, Spain.<br />
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China - [http://www.sibs.ac.cn/synbio/index.asp "Six-Academy Synthetic Biology Symposium - The enabling technology of Synthetic Biology"]<br />
<br />
- 12-14 October 2011 <br><br />
<br />
- Shanghai, China.<br />
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China - [http://www.csh-asia.org/design11.html 2011 CSHA Symposium "Design and Synthesis of Biological Systems"]<br />
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- 7-11 November 2011 <br><br />
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- Suzhou, China.<br />
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== Introduction to RoSBNet ==<br />
RoSBNet (Robust Synthetic Biology Network) brings together people working in [[:Category:Synthetic Biology|'''Synthetic''']] and Systems Biology as well as Systems/Control Engineers, electrical, chemical, computer engineers, Physicists and Mathematicians to address the theoretical and practical challenges of designing new robust biological networks or modifying already existing ones, which have to function inside uncertain biological environments, all the way from parts to whole systems. The network will focus on the Ethical, Legal and Societal Issues that are raised by advances in Synthetic Biology, aiming to create a fruitful discussion on how such concerns can be balanced by the potential usefulness of the many applications, such as environmental cleanup, fuel generation and healthcare. The objective is to transfer knowledge and develop a fruitful discussion and cross-fertilization of ideas on ''modelling, analysis, design and construction of synthetic biological networks'' creating a mobility and communication between control/electrical/computer engineering, biology, mathematics and the social sciences as well as with Industry. The goal is to create a cohesive community that can respond effectively to research challenges, funding opportunities and international activities. <br/><br />
<br />
Synthetic Biology is a new research field which aims in designing new or modifying existing biological pathways in order to produce systems with superior or different properties, usually for a novel application. In the related field of systems biology, it is recognized that it is impossible to infer the biological network behaviour by just listing its components but rather the whole feedback mechanism linking them needs to be considered; the same is true in every Synthetic Biology design. However, these designs need to be implemented inside a cellular environment and a major challenge that synthetic biology has to face is that the effect of the interactions of the new pathways with the cellular environment need to be taken into account during the design or redesign process. This is unlike any other engineering design procedure, such as electrical circuit or computer engineering design, where the behaviour of simple parts (e.g., resistors), of more complicated components (e.g., transistors) or even of whole systems (e.g., complete circuits) can be predicted (and eventually measured and verified) efficiently after implementation. This unique feature to Synthetic Biology design poses new challenges to engineering and mathematics. At the same time, many engineering disciplines, such as control and computer engineering, have for years been dealing with the analysis and design of complex systems that have to operate robustly in uncertain environments and therefore have a lot to contribute towards constructing biological modules, whether these are parts, pathways, artificial cells or cultures/tissues with performance guarantees within an uncertain environment. <br/><br />
<br />
== Organisation of the Network ==<br />
It is important to emphasise that the objectives of this network are difficult to achieve by individuals alone – instead, an integrated collaboration between members of the whole network would be required. RoSBNet creates these necessary collaborative links. The activities aim to benefit not only the network as a whole, but also the individuals who will widen their research outreach through the network interactions. <br/><br />
<br />
The figure below shows the topics that will be investigated in the following three years. The challenge is to exchange views and expertise on how to construct robust biological networks at different organisational scales. From the '''Biology''' side, in the first year we will look at the gene regulatory network level, in the second year at signal transduction/metabolic/protein-protein interaction pathways and in the third year at how whole cells can be constructed. At the same time, every year we will be looking at paradigms from '''Electrical and Computer engineering''' that are directly related to the biological scale – resistors/capacitors/inductors and small circuits (op-amps, transistors etc) in the first year, larger circuits in the second year and computer networks and protocols/modularity/architecture in the third year. In parallel to these there will be a '''control/mathematical''' direction which will discuss modelling for design at these different organizational levels. Two common themes for all three years will be measurement – i.e., how one can build devices that evaluate the performance of designs – and '''ELSI''', i.e., what are the ethical, legal, social, philosophical, economical and other issues that are raised by Synthetic Biology research.<br/><br />
<br />
[[Image:SB2_color_small.png||thumb|1000px|centre]]<br />
<br />
== RoSBNet will network in 3 ways: ==<br />
# Via a series of [[Current events| yearly, multi-day, workshops]] with the next hosted on 20th-22nd July 2011 in Oxford.<br />
# Via this online [[Main Page|Wiki]]<br />
# Via an email-based [mailto:rosbnet-subscribe@maillist.ox.ac.uk newsletter mailing list]. To self-subscribe please send a blank mail to: [mailto:rosbnet-subscribe@maillist.ox.ac.uk rosbnet-subscribe@maillist.ox.ac.uk]<br />
<center><br />
[[Image:BBSRC.jpg|link = http://www.bbsrc.ac.uk|150xpx|left]] [[Image:EPSRC.jpg|link=http://www.bbsrc.ac.uk|150xpx|left]] [[Image:ESRC.jpg|link=http://www.esrc.ac.uk|150xpx|left]] [[Image:AHRC.jpg|link = http://www.ahrc.ac.uk|150xpx|left]]<br />
</center><br />
__NOTOC__</div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Member_List&diff=987Member List2011-08-26T13:58:39Z<p>Antonis: </p>
<hr />
<div>= RoSBNet Members =<br />
<br />
Below you will find a list of RoSBNet members, with links to their websites for more information.<br />
<br />
== Engineering/Mathematics Researchers == <br />
<br />
* [http://sysos.eng.ox.ac.uk/control/sysos/index.php/User:Antonis Antonis Papachristodoulou]<br><br />
* [http://www.ist.uni-stuttgart.de/allgower/allgower.shtml Frank Allgower]<br><br />
* [http://www3.imperial.ac.uk/people/m.barahona Mauricio Barahona]<br><br />
* [http://www.eee.strath.ac.uk/~hongyue/ Hong Yue]<br><br />
* [http://www.eee.manchester.ac.uk/aboutus/staff/show.html?ea=William.Heath William Heath]<br><br />
* [http://biology.st-andrews.ac.uk/vannesmithlab/ Anne Smith]<br><br />
* [http://www.rdg.ac.uk/icmr/about/staff/icmr-m-tindall.asp Marcus Tindall]<br><br />
* [http://www.montefiore.ulg.ac.be/~bullinger/ Eric Bullinger] <br> <br />
* [http://www.gla.ac.uk/departments/aerospace/staff/academicstaff/jongraekim Jongrae Kim]<br><br />
* [http://control.ee.ethz.ch/index.cgi?page=people Elias August] <br><br />
* [http://www.sbs.ox.ac.uk/faculty/Reed-Tsochas+Felix/ Felix Reed-Tsochas] <br><br />
* [http://www.stats.ox.ac.uk/people/academic_staff/jotun_hein Jotun Hein] <br><br />
* [http://www.eng.ox.ac.uk/control/peopleJA.shtml James Anderson] <br><br />
* [http://www.eng.ox.ac.uk/samp/people.html Patrick McSharry] <br><br />
* [http://www.ist.uni-stuttgart.de/~waldherr/ Steffen Waldherr] <br><br />
* [http://www3.imperial.ac.uk/people/r.tanaka Reiko Tanaka] <br><br />
* [http://www.comlab.ox.ac.uk/people/Jonathan.Whiteley/ Jonathan Whiteley] <br> <br />
* [http://www.physics.ox.ac.uk/users/kapanidis/ Achillefs Kapanidis] <br> <br />
* [http://www.staff.ncl.ac.uk/d.j.wilkinson/ Darren Wilkinson] <br> <br />
* [http://www.comlab.ox.ac.uk/people/David.Gavaghan/ David Gavaghan] <br> <br />
* [http://www.le.ac.uk/eg/dgb3/ Declan Bates] <br><br />
* [http://www-control.eng.cam.ac.uk/~jmg77/ Jorge Goncalves] <br><br />
* [http://www.eecs.umich.edu/~ddv/ Domitilla del Vecchio] <br><br />
* [http://biochemistry.ucsf.edu/labs/elsamad/people/Hana_El_Samad/hana_el_samad.html Hana El-Samad] <br><br />
* [http://www.bionanotechnology.ox.ac.uk/index.php?option=com_content&task=view&id=24&Itemid=50 John Ryan] <br><br />
* [http://www.me.ucsb.edu/dept_site/people/khammash_page.htm Mustafa Khammash ]<br><br />
* [http://people.maths.ox.ac.uk/~maini/ Philip Maini] <br><br />
* [http://www.physics.ox.ac.uk/cm/cmt/jones/ Nick Jones] <br><br />
* [http://www.eng.ox.ac.uk/control/peopleSD.shtml Steve Duncan] <br><br />
* [http://www-control.eng.cam.ac.uk/Homepage/officialweb.php?id=232 Guy-Bart Stan] <br><br />
* [http://melykuti.web.elte.hu/index.htm Bence Melykuti] <br><br />
* [http://www-control.eng.cam.ac.uk/~aoh21/ Abdullah Hamadeh] <br><br />
* [http://www.eng.ox.ac.uk/~stcman/people.shtml Edward Hancock] <br><br />
* [http://www.st-hildas.ox.ac.uk/index.php/fellowsandlecturers/alubansky.html Alex Lubansky] <br><br />
* [http://www3.imperial.ac.uk/people/natalja.strelkowa06 Natalja Strelkowa] <br><br />
* [http://www.soton.ac.uk/ses/people/staff/ChipperfieldAJ.html Andrew Chipperfield] <br><br />
* [http://www.secam.ex.ac.uk/academic.dhtml?group=academic%20staff|teaching%20fellows&sid=1001 Orkun Soyer] <br><br />
* [http://www.enm.bris.ac.uk/anm/staff/enmdb/home.html Mario Di Bernardo] <br><br />
* [http://users.ox.ac.uk/~dpag0022/index.htm Eric Werner] <br><br />
* [http://mpf.biol.vt.edu/lab_website/people/Tongli_Zhang/ Tongli Zhang] <br><br />
* [http://www.ieeecss.org/main/mab-programs/distinguished-lecturers-program Rodolphe Sepulchre] <br><br />
<br />
== Biology/Biochemistry Researchers == <br />
* [http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=565 Judy Armitage] <br> <br />
* [http://www.abdn.ac.uk/ims/staff/details.php?id=i.stansfield Ian Stansfield]<br><br />
* [http://www.brookes.ac.uk/res/experts/profiles/david_fell David Fell]<br><br />
* [http://www.plantsci.cam.ac.uk/research/alexwebb.html Alex Webb] <br><br />
* [http://swainlab.bio.ed.ac.uk/details.php Peter Swain] <br><br />
* [http://www.eng.ox.ac.uk/~cheit/ Ian Thompson] <br><br />
* [http://dps.plants.ox.ac.uk/plants/Staff/LeeSweetlove.aspx Lee Sweetlove] <br><br />
* [http://www.lincoln.ox.ac.uk/content/view/832/40/ Mark Roberts] <br><br />
* [http://www.pmb.ox.ac.uk/Fellows_Staff/Fellow_and_Staff_Profiles.php?profile=146 Steve Porter] <br><br />
* [http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php/User:MarkChang Yo-Cheng (Mark) Chang] <br><br />
* [http://waterfall.union.edu/Staff_Directory/Union/Electrical__Computer_Engineering/Hooshangi_Sara_.php Sara Hooshangi] <br><br />
* [http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=593 Bela Novak] <br><br />
* [http://www.sysbio.ox.ac.uk/People/GW.html George Wadhams] <br><br />
* [http://sbcb.bioch.ox.ac.uk/sansom.php Mark Sansom] <br><br />
* [http://www.sheffield.ac.uk/civil/staff/academic/wh.html Wei Huang] <br><br />
* [http://www2.le.ac.uk/departments/engineering/ William Bryant] <br><br />
* [http://www.shef.ac.uk/materials/staff/claeyssens.html Frederik Claeyssens] <br><br />
* [http://www.cs.ncl.ac.uk/people/j.s.hallinan Jennifer Hallinan] <br><br />
* [http://www3.imperial.ac.uk/people/k.polizzi Karen Polizzi] <br><br />
* [http://www2.warwick.ac.uk/fac/sci/whri/about/staff/kdenby/ Katherine Denby] <br><br />
* [http://www.ceas.manchester.ac.uk/aboutus/staff/show.html?ea=hans.westerhoff Hans Westerhoff] <br><br />
* [http://www.eda.kent.ac.uk/school/staff_detail.aspx?id=330 Najl Valeyev] <br><br />
* [http://www.dpag.ox.ac.uk/research/cardiac_science/peter_robbins/robbins_members Nayia Petousi] <br><br />
* [http://www.mib.manchester.ac.uk/postgraduate/DTC/ Victoria Jackson] <br><br />
<br />
== Researchers from the Ethical, Legal and Social Sciences == <br />
* [http://web.comlab.ox.ac.uk/Annamaria.Carusi/ Annamaria Carusi]<br><br />
* [http://www.sbs.ox.ac.uk/insis/people/sugden+chris.htm Chris Sugden]<br><br />
* [http://www.ethox.org.uk/people/michael-parker Michael Parker]<br><br />
* [http://people.bath.ac.uk/ak280/ Alexander Kelle] <br><br />
* [http://www.ifom-ieo-campus.it/research/boniolocv.php Giovanni Boniolo] <br><br />
* [http://www.practicalethics.ox.ac.uk/nstaff.htm Julian Savulescu] <br><br />
* [http://www.philosophy.ox.ac.uk/members/marianne_talbot Marianne Talbot] <br><br />
* [http://www.bep.ox.ac.uk/our%20people.html Mark Sheehan] <br><br />
* [http://www.neuroethics.ox.ac.uk/node/19 Steve Clarke] <br><br />
* [http://www.ethox.org.uk/people/jane-kaye Jane Kaye] <br><br />
* [http://www.practicalethics.ox.ac.uk/nstaff.htm#staff Thomas Douglas] <br><br />
* [http://helex.medsci.ox.ac.uk/staff/researchers/liam-curren Liam Curren] <br><br />
* [http://www.sussex.ac.uk/Units/spru/hsp/People/James%20Revill.html James Revill] <br></div>Antonishttp://rosbnet.org/wiki/wiki/index.php?title=Member_List&diff=986Member List2011-08-26T13:58:19Z<p>Antonis: </p>
<hr />
<div>= RoSBNet Members =<br />
<br />
Below you will find a list of RoSBNet members, with links to their websites for more information.<br />
<br />
== Engineering/Mathematics Researchers == <br />
<br />
* [http://sysos.eng.ox.ac.uk/control/sysos/index.php/User:Antonis Antonis Papachristodoulou]<br><br />
* [http://www.ist.uni-stuttgart.de/allgower/allgower.shtml Frank Allgower]<br><br />
* [http://www3.imperial.ac.uk/people/m.barahona Mauricio Barahona]<br><br />
* [http://www.eee.strath.ac.uk/~hongyue/ Hong Yue]<br><br />
* [http://www.eee.manchester.ac.uk/aboutus/staff/show.html?ea=William.Heath William Heath]<br><br />
* [http://biology.st-andrews.ac.uk/vannesmithlab/ Anne Smith]<br><br />
* [http://www.rdg.ac.uk/icmr/about/staff/icmr-m-tindall.asp Marcus Tindall]<br><br />
* [http://www.montefiore.ulg.ac.be/~bullinger/ Eric Bullinger] <br> <br />
* [http://www.gla.ac.uk/departments/aerospace/staff/academicstaff/jongraekim Jongrae Kim]<br><br />
* [http://control.ee.ethz.ch/index.cgi?page=people Elias August] <br><br />
* [http://www.sbs.ox.ac.uk/faculty/Reed-Tsochas+Felix/ Felix Reed-Tsochas] <br><br />
* [http://www.stats.ox.ac.uk/people/academic_staff/jotun_hein Jotun Hein] <br><br />
* [http://www.eng.ox.ac.uk/control/peopleJA.shtml James Anderson] <br><br />
* [http://www.eng.ox.ac.uk/samp/people.html Patrick McSharry] <br><br />
* [http://www.ist.uni-stuttgart.de/~waldherr/ Steffen Waldherr] <br><br />
* [http://www3.imperial.ac.uk/people/r.tanaka Reiko Tanaka] <br><br />
* [http://www.comlab.ox.ac.uk/people/Jonathan.Whiteley/ Jonathan Whiteley] <br> <br />
* [http://www.physics.ox.ac.uk/users/kapanidis/ Achillefs Kapanidis] <br> <br />
* [http://www.staff.ncl.ac.uk/d.j.wilkinson/ Darren Wilkinson] <br> <br />
* [http://www.comlab.ox.ac.uk/people/David.Gavaghan/ David Gavaghan] <br> <br />
* [http://www.le.ac.uk/eg/dgb3/ Declan Bates] <br><br />
* [http://www-control.eng.cam.ac.uk/~jmg77/ Jorge Goncalves] <br><br />
* [http://www.eecs.umich.edu/~ddv/ Domitilla del Vecchio] <br><br />
* [http://biochemistry.ucsf.edu/labs/elsamad/people/Hana_El_Samad/hana_el_samad.html Hana El-Samad] <br><br />
* [http://www.bionanotechnology.ox.ac.uk/index.php?option=com_content&task=view&id=24&Itemid=50 John Ryan] <br><br />
* [http://www.me.ucsb.edu/dept_site/people/khammash_page.htm Mustafa Khammash ]<br><br />
* [http://people.maths.ox.ac.uk/~maini/ Philip Maini] <br><br />
* [http://www.physics.ox.ac.uk/cm/cmt/jones/ Nick Jones] <br><br />
* [http://www.eng.ox.ac.uk/control/peopleSD.shtml Steve Duncan] <br><br />
* [http://www-control.eng.cam.ac.uk/Homepage/officialweb.php?id=232 Guy-Bart Stan] <br><br />
* [http://melykuti.web.elte.hu/index.htm Bence Melykuti] <br><br />
* [http://www-control.eng.cam.ac.uk/~aoh21/ Abdullah Hamadeh] <br><br />
* [http://www.eng.ox.ac.uk/~stcman/people.shtml Edward Hancock] <br><br />
* [http://www.st-hildas.ox.ac.uk/index.php/fellowsandlecturers/alubansky.html Alex Lubansky] <br><br />
* [http://www3.imperial.ac.uk/people/natalja.strelkowa06 Natalja Strelkowa] <br><br />
* [http://www.soton.ac.uk/ses/people/staff/ChipperfieldAJ.html Andrew Chipperfield] <br><br />
* [http://www.secam.ex.ac.uk/academic.dhtml?group=academic%20staff|teaching%20fellows&sid=1001 Orkun Soyer] <br><br />
* [http://www.enm.bris.ac.uk/anm/staff/enmdb/home.html Mario Di Bernardo] <br><br />
* [http://users.ox.ac.uk/~dpag0022/index.htm Eric Werner] <br><br />
* [http://mpf.biol.vt.edu/lab_website/people/Tongli_Zhang/ Tongli Zhang] <br><br />
* [http://www.ieeecss.org/main/mab-programs/distinguished-lecturers-program Rodolphe Sepulchre] <br><br />
<br />
== Biology/Biochemistry Researchers == <br />
* [http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=565 Judy Armitage] <br> <br />
* [http://www.abdn.ac.uk/ims/staff/details.php?id=i.stansfield Ian Stansfield]<br><br />
* [http://www.brookes.ac.uk/res/experts/profiles/david_fell David Fell]<br><br />
* [http://www.plantsci.cam.ac.uk/research/alexwebb.html Alex Webb] <br><br />
* [http://swainlab.bio.ed.ac.uk/details.php Peter Swain] <br><br />
* [http://www.eng.ox.ac.uk/~cheit/ Ian Thompson] <br><br />
* [http://dps.plants.ox.ac.uk/plants/Staff/LeeSweetlove.aspx Lee Sweetlove] <br><br />
* [http://www.lincoln.ox.ac.uk/content/view/832/40/ Mark Roberts] <br><br />
* [http://www.pmb.ox.ac.uk/Fellows_Staff/Fellow_and_Staff_Profiles.php?profile=146 Steve Porter] <br><br />
* [http://sysos.eng.ox.ac.uk/control/RoSBNet/index.php/User:MarkChang Yo-Cheng (Mark) Chang] <br><br />
* [http://waterfall.union.edu/Staff_Directory/Union/Electrical__Computer_Engineering/Hooshangi_Sara_.php Sara Hooshangi] <br><br />
* [http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=593 Bela Novak] <br><br />
* [http://www.sysbio.ox.ac.uk/People/GW.html George Wadhams] <br><br />
* [http://sbcb.bioch.ox.ac.uk/sansom.php Mark Sansom] <br><br />
* [http://www.sheffield.ac.uk/civil/staff/academic/wh.html Wei Huang] <br><br />
* [http://www2.le.ac.uk/departments/engineering/ William Bryant] <br><br />
* [http://www.shef.ac.uk/materials/staff/claeyssens.html Frederik Claeyssens] <br><br />
* [http://www.cs.ncl.ac.uk/people/j.s.hallinan Jennifer Hallinan] <br><br />
* [http://www3.imperial.ac.uk/people/k.polizzi Karen Polizzi] <br><br />
* [http://www2.warwick.ac.uk/fac/sci/whri/about/staff/kdenby/ Katherine Denby] <br><br />
* [http://www.ceas.manchester.ac.uk/aboutus/staff/show.html?ea=hans.westerhoff Hans Westerhoff] <br><br />
* [http://www.eda.kent.ac.uk/school/staff_detail.aspx?id=330 Najl Valeyev] <br><br />
* [http://www.dpag.ox.ac.uk/research/cardiac_science/peter_robbins/robbins_members Nayia Petousi] <br><br />
* [http://www.mib.manchester.ac.uk/postgraduate/DTC/ Victoria Jackson] <br><br />
<br />
== Researchers from the Ethical, Legal and Social Sciences == <br />
* [http://web.comlab.ox.ac.uk/Annamaria.Carusi/ Annamaria Carusi]<br><br />
* [http://www.sbs.ox.ac.uk/insis/people/sugden+chris.htm Chris Sugden]<br><br />
* [http://www.ethox.org.uk/people/michael-parker Michael Parker]<br><br />
* [http://people.bath.ac.uk/ak280/ Alexander Kelle] <br><br />
* [http://www.ifom-ieo-campus.it/research/boniolocv.php Giovanni Boniolo] <br><br />
* [http://www.practicalethics.ox.ac.uk/nstaff.htm Julian Savulescu] <br><br />
* [http://www.philosophy.ox.ac.uk/members/marianne_talbot Marianne Talbot] <br><br />
* [http://www.bep.ox.ac.uk/our%20people.html Mark Sheehan] <br><br />
* [http://www.neuroethics.ox.ac.uk/node/19 Steve Clarke] <br><br />
* [http://www.ethox.org.uk/people/jane-kaye Jane Kaye] <br><br />
* [http://www.practicalethics.ox.ac.uk/nstaff.htm#staff Thomas Douglas] <br><br />
* [http://helex.medsci.ox.ac.uk/staff/researchers/liam-curren Liam Curren] <br><br />
* [http://www.sussex.ac.uk/Units/spru/hsp/People/James%20Revill.html Jamie Revill] <br></div>Antonis